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theRedditUser31415 t1_iz1b2of wrote

Reply to comment by Damerman in Study in fruit flies found that the most promising anti-ageing drug rapamycin prolongs the lifespan, and the development of age-related pathological changes in the gut, of female fruit flies, but not in males. Concluding that the sex is a crucial factor in the effectiveness of anti-ageing drugs by giuliomagnifico

I guess they’re talking about this? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4801794/#:~:text=Rapamycin%20mediates%20immunosuppressive%20effects%20through,thereby%20blocking%20proliferation%5B33%5D. Rapamyacin has potent immunosuppressive effects.

And according to this https://www.cancer.gov/publications/dictionaries/cancer-terms/def/rapamycin#:~:text=Rapamycin%20blocks%20certain%20white%20blood,of%20serine%2Fthreonine%20kinase%20inhibitor, rapamycin is classified as an antibiotic.

However they’re definitely wrong on the human part as it is already used in humans for multiple purposes, like organ transplants.

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HappyBavarian t1_iz1hcq2 wrote

Rapamycin was initially developed as an antibiotic. The immunosuppressant properties have been discovered afterwards. Hence it was taken off the market. It made it's come-back some time ago for OT patients. Maybe I should have formulated this clearer in order not to confuse people unfamiliar with the substance.

I know that it is used in OT recipients, because I have been prescribing during my work.

I would rather not see it as a potential anti-aging drug because of its immunosuppressant properties and possible fatal side effects due to infection in an immunocompromised state.

Thanks for your response and the links.

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