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CuteDerpster t1_j1e2081 wrote

Reply to comment by OneHumanPeOple in Study: Oral Cannabis Products Show Long-Term Safety and Efficacy in Patients by GivenAllTheFucksSry

Boofing may actually make it less effective.

Sure, more thc enters your bloodstream, but an important thing for oral cannabis is the first pass metabolism where thc is converted to 11-OH-THC, which is just as, if not even more psychoactive than thc.

Boofing may be as short lived as inhalation, while oral consumption works for hours on end.

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OneHumanPeOple t1_j1e52ns wrote

I actually don’t have enough of that enzyme that does the conversion so it takes about 4 hours for me to feel any effect and then I am extremely high for about 3 days. My first experience with oral administration was an absolute living nightmare where I was unable to leave what I thought was a sofa for days. Turns out it was an unassembled ikea futon, essentially a pile of boards that I laid on for 72 hours as people came and went all around me.

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CuteDerpster t1_j1e6718 wrote

Yeah that sounds horrible.

Considering my body has some weird kinks with methylation and breakdown of estrogen metabolites.... Maybe I should do an ultra low dose the first time I try edibles x) do NOT want to experience a 3 day trip.

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OneHumanPeOple t1_j1e7hta wrote

It’s Cytochrome P450, a liver enzyme. So you may be completely fine.

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CuteDerpster t1_j1ed6vb wrote

Erm..... Yes, the enzyme to metabolize estrogen in the liver is also of the cyp 450 family.

Cyp (450) 3a4.

Cyp3a4 as well as cyp2c9 are the ones responsible for thc metabolism.

Both of the cytochrome 450 family.

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imasitegazer t1_j1edy5t wrote

Did you learn this through genetic testing?

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CuteDerpster t1_j1eif05 wrote

This I learned by googling.

My issues with methylation I noticed when I took methylsulfonymethan for skin and nail benefits and it really messed me up x)

As for my issues with estrogen..... I have to take endogenous estrogen, and despite very low doses, my blood levels were sky high, way higher than they should be.

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imasitegazer t1_j1ep285 wrote

I have high estrogen and low progesterone so I take progesterone for two weeks of the month.

I’ve heard of genetic testing for the MTHER gene, so I was wondering if the Cyp450 was a similar test.

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