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Zestfullyclean87 t1_j2pzlwb wrote

Reply to comment by messopotatoesmia in A study on obese patients suggests the gut microbiome affects obesity levels. Microbial diversity decreased in obese subjects, and the reduction trend was correlated with the severity of obesity. by glawgii

It “fails” because we don’t defy the laws of physics. Energy cannot be created nor destroyed. If you take in more energy than you expend, it’s not just gonna go away, it’s gonna be stored, in this case, as fat

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messopotatoesmia t1_j2q19ho wrote

Why don't we just stop eating when we have enough? We're wired with chemical sensors all over the place to determine the content of our food. Some foods are also immediately satiating - for example, chicken bone broth.

There's a missing puzzle piece here, which is why they call it an obesity epidemic - it behaves like a disease, and no-one understands the root cause yet.

We also don't normally extract anywhere near the total energy from our food that it contains, so comparisons with a bomb calorimeter aren't accurate. Microbiome diversity determines whether or not - for example - you break down cellulose in your colon. If you've got methanogenic bacteria in your gut, you're going to put on weight when someone else without them might not.

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Zestfullyclean87 t1_j2q6v3k wrote

Well you seem to think that, if a food is satiating, then we robotically stop eating. That’s not the case.

As for why we don’t stop eating when we have enough… you’re forgetting that a lot of people are being raised on very large portions. When you’ve eaten that way your whole life, you’ve pretty much trained yourself to not be satiated until you’ve already had too much. Chicken stock does not make you stop

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messopotatoesmia t1_j2qec1n wrote

That's pretty much the definition of satiating. It sates the urge.

I grew up in another country. Got much fatter once I was here. And chicken bone broth makes me rapidly satiated; even foods cooked in it. I eat it, my hunger gives way rapidly to feeling annoyingly full in about 1/4 the quantity it would normally take. My theory is that it's rich in L-Glutamine, calcium and magnesium, and that's enough to trip the mechanism and to provide enough raw precursors for the gut lumen to generate GLP-1 in large quantities, a bit like semaglutide, but that's just a hunch.

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Zestfullyclean87 t1_j2qj6yx wrote

So you think being satiated forces a person to put the food down?

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messopotatoesmia t1_j2qqv52 wrote

Unless they have a busted ventromedial nucleus of the hypothalamus, yes.

If that's shot, they'll eat until they burst, but that's very unlikely - though the cause might be glutamate toxicity.

It might happen with people with poor gut barrier function if they consume a lot of wheat; wheat-germ agglutinin (WGA) binds leptin receptors, blocking them. Leptin inhibits hunger. Similarly, WGA also binds insulin receptors, so it's a bit of a double whammy; it takes the brakes off hunger and increases blood glucose, causing it to be more likely to be stored as fat. Regardless, hunger increases.

You seem to be quibbling over the definition of satiety. Satiety means "feels full/done with food". By definition, if someone experience satiety, their hunger is sated, and stops.

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