Shape of a protein predicted by two different AI models (ESMFold on the left, AlphaFold on the right)wazabee t1_iw9uoon wrote
Reply to comment by vhu9644 in Shape of a protein predicted by two different AI models (ESMFold on the left, AlphaFold on the right) by greentea387
im a biochemist, so yes i know what a protein is. Im trying to explain the importance of maintaining the 3d structure of a protein to its function. Both proteins have the same sequence, but there is a slight difference in what the software rendered. Now, based on the sequence, a cell would reliably recreate the same protein. However, in the context of having 2 slightly different structures from the same amino acid strand, yes, you can have widely varying functions that result depending on the original purpose of the peptide strand.
vhu9644 t1_iwau2w1 wrote
And I’m a synthetic biologist in protein engineering. What I’m skeptical about is that for this protein specifically, this change in structure plays a major role in function determination, due to its simplicity, and that we are seeing two distinct folds that are locked from each other.
The point ultimately is moot, the protein chosen is a membrane bound protein, so the lipid layer will provide stabilization.
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