LOL I had to look it up quick:

"For the first and last time in U.S. history, a president found himself running against his vice president.

Things got ugly fast. Jefferson's camp accused President Adams of having a "hideous hermaphroditical character, which has neither the force and firmness of a man, nor the gentleness and sensibility of a woman.""

https://www.cnn.com/2008/LIVING/wayoflife/08/22/mf.campaign.slurs.slogans/