BurrDurrMurrDurr

BurrDurrMurrDurr t1_je14r38 wrote

Reply to What part of your commute gives you the biggest headache? by [deleted]

I’ll throw my non-driving one out here:

When I ride my bike to work (South End, Mass/Cass) from Porter Square. Half the commute is ok, I ride in protected lanes to the river and then to Mass bridge where I only have to worry about pedestrians.

THEN DOWN MASS AVE from the bridge. Holy shit I almost die 3-4 times every commute.

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BurrDurrMurrDurr t1_jcv38ub wrote

Reply to Manual Transmission Driving Lessons by jeffkeyrouz87

These don’t really exist anymore.

You’d have to:

  1. Know someone with a manual willing to let you drive it
  2. Lease or buy one
  3. SUPER DICK MOVE rent one on Turo and have someone that knows how to drive one teach you.

I know a couple people that did option 3 in the last few years and it’s super fucked up. I just ended up buying one and re-learned on my own car.

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BurrDurrMurrDurr t1_j79l23p wrote

Reply to comment by Jumpsuit_boy in New evidence suggests that ‘hybrid’ immunity, the result of both vaccination and a bout of COVID-19, can provide partial protection against reinfection for at least eight months. Immunity acquired by booster vaccination alone seems to fade somewhat faster. by MistWeaver80

HPV vaccination induces memory B cells^(1) and there are sustained serum antibodies that suggest LLPCs are also vaccine induced^(2)

^(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175219/

^(2): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9229470/

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BurrDurrMurrDurr t1_j76stja wrote

Reply to comment by Jumpsuit_boy in New evidence suggests that ‘hybrid’ immunity, the result of both vaccination and a bout of COVID-19, can provide partial protection against reinfection for at least eight months. Immunity acquired by booster vaccination alone seems to fade somewhat faster. by MistWeaver80

Yes, Tdap (tetanus, diphtheria, pertussis) vaccine is good for decades.

Measles, smallpox and HPV vaccines also generate LLPCs and provide protection for a long time.

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BurrDurrMurrDurr t1_j76rxyt wrote

Reply to comment by [deleted] in New evidence suggests that ‘hybrid’ immunity, the result of both vaccination and a bout of COVID-19, can provide partial protection against reinfection for at least eight months. Immunity acquired by booster vaccination alone seems to fade somewhat faster. by MistWeaver80

Oo that's a great question. That is hard to test since COVID exposure =/= COVID infection. COVID re-infection DOES effectively "reset" your antibody levels assuming you clear the virus after the 2nd infection. If I had to educated-guess this I would say at best, exposure within 7 months of cleared infection might sustain your antibody levels a little longer but again, if there are no memory B or LLPCs made, they will still wane.

After first infection your adaptive immune response generates B cells that make antibodies specifically for the virus. Those B cells and antibodies "stick around" for a while until they wane. Generally it seems your body has elevated and protective amounts of antibodies for at least 3 months after infection. Then they start to drop and GENERALLY after about 7-8 months. At this point a 2nd re-infection is not only possible but your body will react similarly to the first infection, although you should be able to clear it quicker.

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BurrDurrMurrDurr t1_j755pz3 wrote

Reply to New evidence suggests that ‘hybrid’ immunity, the result of both vaccination and a bout of COVID-19, can provide partial protection against reinfection for at least eight months. Immunity acquired by booster vaccination alone seems to fade somewhat faster. by MistWeaver80

I currently study infectious diseases and have done some work on SARS-CoV-2, maybe I can clear some things up for people.

The "holy grail" for a successful vaccine is triggering the generation of memory B cells and long lived plasma cells. Memory B cells are long-lived, quiescent cells that rapidly respond to antigen when activated and long lived plasma cells (LLPCs) constitutively secrete antibodies throughout their lives and can live as long as we do.

Studies have shown that SARS-CoV-2 vaccination elicit both T and B cell responses and generate antibodies but these antibodies seem to wane after 3-6 months; no LLPCs. This article is highlighting research that shows having natural infection + a vaccination seems to elicit an antibody response that is longer than only vaccination. Data in my lab shows 3-5 months vs 7-10 months and lots of papers I've seen show similar trends.

That's all this article is saying. I don't think it's trying to claim one method is better than another, or to get infected on purpose. We are all (in the field) trying to figure out how to trigger this differentiation into long lived plasma and memory B cells from a vaccine. There are tons of factors mediating this obstacle including mutation rate. Measles and polio, for example, are very stable viruses and don't mutate as often. This contributes to the success of their vaccines as they provide largely lifelong immunity.

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BurrDurrMurrDurr t1_j5rzw9d wrote

Reply to comment by Ruthrfurd-the-stoned in Declines in the populations of the world’s largest carnivores—such as lions, tigers, and wolves—may be more strongly associated with human socioeconomic growth than habitat loss or climate change, suggests a study. by MistWeaver80

It’s Nature Communications. While I think overall it’s a solid journal, they published 7400 articles last year.. that’s about 600/month. Nature, on the other hand, does 800-1000 per YEAR.

My point is I’ve seen some suspect science get accepted into Nature Comms but it seems a symptom of volume.

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