Kandiru
Kandiru t1_isimfb1 wrote
Reply to comment by promonk in When it's said 99.9% of human DNA is the same in all humans, is this referring to only coding DNA or both coding and non-coding DNA combined? by PeanutSalsa
The 1000 genome project used populations around the world
http://ftp.1000genomes.ebi.ac.uk/vol1/ftp/README_populations.md
Has a list of the ones used.
Kandiru t1_isim3ny wrote
Reply to comment by tsunamisurfer in When it's said 99.9% of human DNA is the same in all humans, is this referring to only coding DNA or both coding and non-coding DNA combined? by PeanutSalsa
Actually there were two competing approaches at the beginning. Venter did sequence himself with shotgun sequencing, while the high fidelity BAC sequencing with Sanger sequencing was done on a range of different individuals spanning the genome.
So the first version of the reference was a mixture of them all.
Kandiru t1_ishg2ww wrote
Reply to comment by promonk in When it's said 99.9% of human DNA is the same in all humans, is this referring to only coding DNA or both coding and non-coding DNA combined? by PeanutSalsa
Say a certain position is a A for 90% of people, but a C for 10%. The A variant is more common than the C.
So when the reference had previously had a C there, in a later version it's often been changed to the most frequent base.
Kandiru t1_ishbuwl wrote
Reply to comment by promonk in When it's said 99.9% of human DNA is the same in all humans, is this referring to only coding DNA or both coding and non-coding DNA combined? by PeanutSalsa
It's no one person's. It's a mishmash of several different high quality genomes, and then over time it's been changed to have the more common variants as the reference rather than the reference being a rare mutation for some genes.
Kandiru t1_is354d8 wrote
Reply to comment by Chlorophilia in Does the salinity of ocean water increase as depth increases? by rhinotomus
Presumably geothermal vents can heat up water which can send it rising?
Kandiru t1_j13acfr wrote
Reply to comment by DillBagner in Ukrainian general warns Putin is preparing new major winter offensive by Promise-Quirky
So this is Ukrainians killing Nazis again? WWII part ii?