PawnWithoutPurpose

PawnWithoutPurpose OP t1_j6minv8 wrote

Reply to comment by Eldwyn23 in The only way I could get my AirPods to not fall out of my ears was to make custom tips by PawnWithoutPurpose

I tried those. I tried the disposable ones, the wax ones and the memory foam ones, but the low frequencies still pass through. That's where active noise-canceling shines. Like my neighbour has a deep booming voice and if they're having a conversion, and I'm trying to sleep the ANC earphones are the only thing that shuts it out.

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PawnWithoutPurpose OP t1_j6iiw52 wrote

Reply to comment by underprivlidged in The only way I could get my AirPods to not fall out of my ears was to make custom tips by PawnWithoutPurpose

True.

But I bought them now and am past the return window so I got to live with it.

I actually bought them mostly for sleeping, as they have the best noise-cancelling for their size. I have trouble sleeping and these really do help a lot.

But you're right, they are heavily overpriced

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PawnWithoutPurpose OP t1_j6ihanw wrote

Reply to The only way I could get my AirPods to not fall out of my ears was to make custom tips by PawnWithoutPurpose

I was using the largest ones but they kept falling out. There were no official larger sizes so I used memory foam tips to put under the original silicone tips. Now they stay in perfectly, but really I think there could have been a better official solution like Apple making XL tips for people with large ears

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PawnWithoutPurpose t1_j470tii wrote

Reply to How do drug trials determine dosage time limits for medications? by dante662

This subject is called pharmacokinetics. How quickly a drug is metabolised and/or cleared from the body. There are various ways to work this out.

I don’t want to say too much here as anything further from me is from memory of a subject I don’t know too much about. But searching pharmacokinetics will give you information on that subject.

It may be worked out in animals, prior to human testing. It could be worked out in the lab via experiments examining enzymatic activity. Metabolism could be worked out by monitoring blood concentrations depending on the drug. Clearance could be worked out by stool, urine monitoring.

It’s a complicated area that I have had maybe two lectures on, so don’t take what I say as gospel

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