Just to add some more details, CCR5-delta32 had been suggested by some to have links to the Black Plague, but as stated in the linked publication, historical evidence and geographic distribution of the allele suggest otherwise, as you alluded to. Still an interesting mutation though and I look forward to seeing what researchers uncover as to why this allele has higher frequencies among some population subgroups and if it is linked to other variants in those populations.
theboredbiochemist t1_it20wim wrote
Reply to comment by Total-News3680 in Natural Selection Driven by the Black Death Linked to Modern-Day Autoimmune Disease: Analysis of DNA from over 200 remains shows that the Black Death selected for immune gene variants that are also risk factors for autoimmune conditions like Crohn's disease. by rjmsci
Just to add some more details, CCR5-delta32 had been suggested by some to have links to the Black Plague, but as stated in the linked publication, historical evidence and geographic distribution of the allele suggest otherwise, as you alluded to. Still an interesting mutation though and I look forward to seeing what researchers uncover as to why this allele has higher frequencies among some population subgroups and if it is linked to other variants in those populations.