xiledone
xiledone t1_ivo3jix wrote
Reply to comment by Saint_Oliver in How do medicines like Aspercreme work to relieve nerve or muscle pain if they are topical and not transdermal? by freakydeku
Both, but heavily depends on the molecule and the cell. The question is more nuanced, so unfortunately so is the answer, cuz the body is so complex there's rarely a straightfoward answer.
But if allowed to overgeneralize, most of it goes inbetween and "through" the wall that the cells make.
xiledone t1_ivo0uta wrote
Reply to How do medicines like Aspercreme work to relieve nerve or muscle pain if they are topical and not transdermal? by freakydeku
Are u asking about mechanism of action? Because it's the same as most nsaids.
If ur asking about absorption, topical application still gets absorbed. Your skin (keratin mainly) is hydrophobic, so it resists water and other charged substances from entering, but there is a hefty list of chemicals that, if touched, can be absorbed into your bloodstream and even be toxic (notable, methylmercury, as only a tiny bit is touched is needed to be lethal, the methyl means it has extra carbon and makes it more like an oil and bypasses the skin's hydrophobic effects easier).
Hydrophobic stuff will resist charged particles, such as water, from interacting, but will allow other hydrophobic stuff, such as oils and anything thats mostly carbon, to interact. For instance, pure lead (a metal, so its charged) isn't that toxic unless u inhale or ingest it, as the skin works well to resist it. However, tetraethyllead (lead with extra carbons) is very toxic via touch.
(Small edit for clarity, oil actually doesn't get absorbed that easily, as its a big molecule, but its the most easily recognizable hydrophobic liquid, so it was used as an example to make the concept easier to grasp. Just wanted to clear that up).
xiledone t1_it30291 wrote
Reply to comment by 4BigData in Natural Selection Driven by the Black Death Linked to Modern-Day Autoimmune Disease: Analysis of DNA from over 200 remains shows that the Black Death selected for immune gene variants that are also risk factors for autoimmune conditions like Crohn's disease. by rjmsci
Read a book
xiledone t1_it01xmi wrote
Reply to comment by Hendriks0709 in Natural Selection Driven by the Black Death Linked to Modern-Day Autoimmune Disease: Analysis of DNA from over 200 remains shows that the Black Death selected for immune gene variants that are also risk factors for autoimmune conditions like Crohn's disease. by rjmsci
No one's born with natural immunity to it that we know of.
I have type O+ and got super sick. (Was double vaccinated)
The blood type and covid study has been debunked countless times.
xiledone t1_izox9wv wrote
Reply to comment by [deleted] in How AI found the words to kill cancer cells by blaspheminCapn
It says molecules, not cells.