"The “most complicated therapy ever” tailors bespoke, genome-edited immune cells to attack tumors" — In First, Scientists Use CRISPR for Personalized Cancer Treatment 🧬

Paywall? Jump it here: https://archive.ph/VRhPp

>

"A small clinical trial has shown that researchers can use CRISPR gene editing to alter immune cells so that they will recognize mutated proteins specific to a person’s tumours. Those cells can then be safely set loose in the body to find and destroy their target."

Hey team, if you're interested in progress studies, check out "The Progress Dashboard", an experimental proof of concept wiki of progress resources. The project concept is very much at the beta stage, so any positive or constructive feedback is most welcome.

Root Study: Foy, S. P. et al. Nature https://doi.org/10.1038/s41586-022-05531-1 (2022).

The following submission statement was provided by /u/tonymmorley:

"The “most complicated therapy ever” tailors bespoke, genome-edited immune cells to attack tumors" — In First, Scientists Use CRISPR for Personalized Cancer Treatment 🧬

Paywall? Jump it here: https://archive.ph/VRhPp

>

"A small clinical trial has shown that researchers can use CRISPR gene editing to alter immune cells so that they will recognize mutated proteins specific to a person’s tumours. Those cells can then be safely set loose in the body to find and destroy their target."

Hey team, if you're interested in progress studies, check out "The Progress Dashboard", an experimental proof of concept wiki of progress resources. The project concept is very much at the beta stage, so any positive or constructive feedback is most welcome.

Root Study: Foy, S. P. et al. Nature https://doi.org/10.1038/s41586-022-05531-1 (2022).

Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/yw8bmz/in_first_scientists_use_crispr_for_personalized/iwi4iqh/

This will be a luxury for the ultra rich while us peasants fight for basic healthcare scraps. Very cool use of the technology though.

[removed]

This is really exciting. I can’t wait to see what else CRISPR will accomplish in my lifetime.

Nice. I’m excited to see how this plays out over the next decade.

I hate this sad future. We need a revolution. Workers, seize the means of crispr genome editing, you have nothing to lose but your paid private healthcare

The “most complicated therapy ever”

I can already see my insurance company denying the treatment, even if it means I die.

Or ask you to sign a "till death" payment plan.

That wouldn't be the insurer, that would be the provider.

[removed]

Cancer survivor here. This is simply not true. They start expensive and then become increasingly cheaper when subject to competition and economies of scale. It really is much cheaper in the long run to save your life than to have you die. Without the initial high price it is less likely that a lot of these avenues would be pursued and that is why the USA is always on the cutting edge of this sort of thing. It is not great in the short term but fantastic in the longer term

[removed]

[removed]

Nice to finally find a use for that drawer in my fridge. Can’t believe they didn’t advertise this as a possible benefit.

Definitely deserved that Nobel prize a few years back.

Why do people keep saying stuff like this? Do you live on Mars or something?

Are cars, phones, electricity, computers, x-rays, etc. only for the rich in your planet?

> The “most complicated therapy ever” tailors bespoke, genome-edited immune cells to attack tumors

Tell me expensive, without saying expensive.

My niece is a type 1 diabetic and has celiac and a third autoimmune disorder with her skin.

I am really hopeful that between CRISPR and stem cells she will an improvement if not a functional cure in my lifetime.

I would argue it’s the one of the most important breakthroughs in biology, ever

Yeah man don’t you hate how the rich get to drive their car to work while we have to ride our horses?

This is so cool. It’s a shame the company is having funding issues and was mismanaged, cause the technology is dope and needs to get to the market.

I’m incredibly optimistic about solving most of our issues. Once we open up these fancy new machine learning algorithms to other functions than visual imagery (they are already using it in some gene sequencing) than I think the discoveries will be found at an exponential rate. ML+CRISPR+advancements in technology to make cluster computing even cheaper (not to mention the possibility of quantum computers entering into the problem solving arena)

Billionaires use iPhones.. think about that

I hadn’t even thought about machine learning in this context. That’s really exciting too.

I hope some of these things will also be able to impact climate change at an exponential rate.

Have you bought a new car recently? We can't get "used gene therapies" at a discount price. A new phone is $300 for the lowest functioning model near the top is over a grand. Otherwise your locked into an unfavorable contract with a business to get it for free (where they more than make up for it by gouging you on service). I could keep going down this list but yes, cars ARE for the wealthy, same with anything but the absolute oldest/most basic phones, computers. In many modern instances those cheap items are literally unable to do many modern necessary things. Buy a 10 year old computer and try to do a video call for a job interview. Yes, there are many many people that can't afford an x ray or have to wait sometimes months to find out they should have been treated earlier. Do you live under a rock?

This is something a lot of people don't realize. The U.S system has its problems, but it has also thrown more resources toward medical research than any other nation in world history.

It is is not just about being expensive, but potentially fatal if things go wrong; you are editing immune cells that perform very dangerous tasks that require being able to tell apart "normal" body cells from "diseased" cancer cells (in this case cancer cells with mutated genes).

​

If the now-reprogrammed immune cells start attacking healthy cells, or if the process of gene editing itself goes wrong and during insertion of the genes into the host there are "unintended rearrangements" (basically oopsies) it could lead to a plethora of things, including but not limited to; chromosome rearrangements and/or chromosomal instability if too much of the DNA is damaged directly or indirectly during "repairs", leukemias, etc.

​

Some of these patients were receiving immuno-depressing therapies for more than a year! You have to balance other medications that goes with it, and let me tell you something about research with the sickly; it is expensive mentally, physically and economically to not only patients, families, practitioners and and all other supporting staff, but you also have to take into account that rarely do these patients present with only that cancer, chances are they are dealing with other concurrent diseases like diabetes or other metabolic syndromes, as well as socioeconomic barriers preventing them from getting proper care.

​

Many things can go wrong, you can throw millions, if not billions of $$$ at it and it is still does not solve the fundamental problem because capital is not the choke point.