I'm a type 1 diabetic and when I was a teenager and young adult I ended up developing such a high degree of resistance (my ratio was 1 unit for every 3g of carbs at the worst) that I nearly made myself into a type 2 diabetic as well. Genetics has some role to play in that but mostly it was me being a idiot. I got diagnosed at 22 months and by the time I turned 14 I had decided "F*** it" and just started doing whatever I wanted. However by the time I turned 21 after being hospitalized over a dozen times in like 7 years and my kidneys starting to fail. I finally got my s*** back together and started taking care of my self. Now a decade later I've somehow managed to come back from the edge, no protein in my urine and my insulin tolerance is in the average range for a type 1 my age. I bring it up cause I feel it is anecdotal evidence of the effects of varying resistance. A type 2 that let themselves get to that point would have never gotten themselves back to normal resistance levels again.