An ACE2-dependent Sarbecovirus in Russian bats is resistant to SARS-CoV-2 vaccines
journals.plos.orgSubmitted by BlitzOrion t3_zjss97 in science
Submitted by BlitzOrion t3_zjss97 in science
It isn't, this is just normal research cataloging observations and discoveries for the pile. Someone in the future in a Sarbecovirus outbreak if it ever happens, can look back at the human knowledge built up over time.
I’m a HUGE fan of basic research. What I dislike is overhyped conclusions.
“While these two viruses are in a viral lineage distinct from SARS-CoV-1 and -2, the RBD from one virus, Khosta 2, was capable of using human ACE2 to facilitate cell entry. Viral pseudotypes with a recombinant, SARS-CoV-2 spike encoding for the Khosta 2 RBD were resistant to both SARS-CoV-2 monoclonal antibodies and serum from individuals vaccinated for SARS-CoV-2.”
It’s not very interesting to randomly test the cross reactivity of antibodies to unrelated viruses. It’s much more important to understand the receptor:RBD dynamics. As a former journal editor at a different journal, I’m surprised this got into PLoS Pathogens.
Great, how did they find that out.
Which bats did the SARS-CoV-2 virus originate from?
In all probability, also some species of horseshoe bat.
the one from blueprint probably
Welcome to r/science! This is a heavily moderated subreddit in order to keep the discussion on science. However, we recognize that many people want to discuss how they feel the research relates to their own personal lives, so to give people a space to do that, personal anecdotes are allowed as responses to this comment. Any anecdotal comments elsewhere in the discussion will be removed and our normal comment rules apply to all other comments.
I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.
[removed]
[removed]
[removed]
[removed]
[removed]
[removed]
[removed]
So Russian bats not Chinese bats?
[removed]
Dear Chinese, please don't go to eat them.
SciGuy45 t1_izwh36s wrote
A distantly related virus that happens to use the same receptor isn’t neutralized by CoV-2 antibodies. How is this a big deal, especially when Omicron is resistant to many monoclonals?