An ACE2-dependent Sarbecovirus in Russian bats is resistant to SARS-CoV-2 vaccines
journals.plos.orgSubmitted by BlitzOrion t3_zjss97 in science
Submitted by BlitzOrion t3_zjss97 in science
Great, how did they find that out.
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Randy fucked it
So Russian bats not Chinese bats?
It isn't, this is just normal research cataloging observations and discoveries for the pile. Someone in the future in a Sarbecovirus outbreak if it ever happens, can look back at the human knowledge built up over time.
Which bats did the SARS-CoV-2 virus originate from?
In all probability, also some species of horseshoe bat.
I’m a HUGE fan of basic research. What I dislike is overhyped conclusions.
“While these two viruses are in a viral lineage distinct from SARS-CoV-1 and -2, the RBD from one virus, Khosta 2, was capable of using human ACE2 to facilitate cell entry. Viral pseudotypes with a recombinant, SARS-CoV-2 spike encoding for the Khosta 2 RBD were resistant to both SARS-CoV-2 monoclonal antibodies and serum from individuals vaccinated for SARS-CoV-2.”
It’s not very interesting to randomly test the cross reactivity of antibodies to unrelated viruses. It’s much more important to understand the receptor:RBD dynamics. As a former journal editor at a different journal, I’m surprised this got into PLoS Pathogens.
the one from blueprint probably
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