SciGuy45
SciGuy45 t1_j8e80cg wrote
Reply to My stripper earnings on Super Bowl Sunday and Monday as compared to the rest of the year [OC] by nerdydancing
Well done more than doubling your earnings
SciGuy45 t1_j0obl0l wrote
Reply to comment by Heres_your_sign in Cambridge scientists have shown that a widely-used drug to treat liver disease can prevent SARS-CoV-2 infection or reduce COVID-19 severity by hot
Probability of prevention was in the 20-50% range according to the paper. Nothing is 100% perfect, and individual anecdotes don’t supersede careful experimentation.
The paper is open access so click the PDF link and read it.
SciGuy45 t1_izx5za4 wrote
Reply to comment by Reasonable_Ticket_84 in An ACE2-dependent Sarbecovirus in Russian bats is resistant to SARS-CoV-2 vaccines by BlitzOrion
I’m a HUGE fan of basic research. What I dislike is overhyped conclusions.
“While these two viruses are in a viral lineage distinct from SARS-CoV-1 and -2, the RBD from one virus, Khosta 2, was capable of using human ACE2 to facilitate cell entry. Viral pseudotypes with a recombinant, SARS-CoV-2 spike encoding for the Khosta 2 RBD were resistant to both SARS-CoV-2 monoclonal antibodies and serum from individuals vaccinated for SARS-CoV-2.”
It’s not very interesting to randomly test the cross reactivity of antibodies to unrelated viruses. It’s much more important to understand the receptor:RBD dynamics. As a former journal editor at a different journal, I’m surprised this got into PLoS Pathogens.
SciGuy45 t1_izwh36s wrote
Reply to An ACE2-dependent Sarbecovirus in Russian bats is resistant to SARS-CoV-2 vaccines by BlitzOrion
A distantly related virus that happens to use the same receptor isn’t neutralized by CoV-2 antibodies. How is this a big deal, especially when Omicron is resistant to many monoclonals?
SciGuy45 t1_izql3x5 wrote
Reply to comment by danellender in How AI found the words to kill cancer cells by blaspheminCapn
Just like nuclear energy, there’s good and nefarious potential with this technology.
SciGuy45 t1_iyr74ql wrote
Reply to Good “experiences” to gift someone in Philly? by Triphae
Magic Gardens. You can sign up to spend a few hours working with the guy on a current project in the neighborhood
SciGuy45 t1_jd0nd43 wrote
Reply to Where to get just a little mulch in South Philly by researching4worklurk
There’s a hardware store at 20th and Pine (Rittenhouse Hardware). Not that close, but a great small store. May C&R on Washington as well?