Reasonable_Ticket_84 t1_izwxlxv wrote on December 12, 2022 at 1:38 PM

Reply to comment by SciGuy45 in An ACE2-dependent Sarbecovirus in Russian bats is resistant to SARS-CoV-2 vaccines by BlitzOrion

It isn't, this is just normal research cataloging observations and discoveries for the pile. Someone in the future in a Sarbecovirus outbreak if it ever happens, can look back at the human knowledge built up over time.

SciGuy45 t1_izx5za4 wrote on December 12, 2022 at 2:45 PM

I’m a HUGE fan of basic research. What I dislike is overhyped conclusions.

“While these two viruses are in a viral lineage distinct from SARS-CoV-1 and -2, the RBD from one virus, Khosta 2, was capable of using human ACE2 to facilitate cell entry. Viral pseudotypes with a recombinant, SARS-CoV-2 spike encoding for the Khosta 2 RBD were resistant to both SARS-CoV-2 monoclonal antibodies and serum from individuals vaccinated for SARS-CoV-2.”

It’s not very interesting to randomly test the cross reactivity of antibodies to unrelated viruses. It’s much more important to understand the receptor:RBD dynamics. As a former journal editor at a different journal, I’m surprised this got into PLoS Pathogens.