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Ezekiel_W OP t1_isaxjev wrote

>Using chemical design and synthesis, the team brought together the Nobel-prize winning technology with therapeutic technology born in their own lab to overcome a critical limitation of CRISPR. Specifically, the groundbreaking work provides a system to deliver the cargo required for generating the gene editing machine known as CRISPR-Cas9. The team developed a way to transform the Cas-9 protein into a spherical nucleic acid (SNA) and load it with critical components as required to access a broad range of tissue and cell types, as well as the intracellular compartments required for gene editing.

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tms102 t1_isb6g9u wrote

Great to see more techniques around crispr keep being developed.

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TemetN t1_isbbe8m wrote

Normally I'd raise an eyebrow and wonder if we never heard of this again or if it became an integral technology, but given the 'delivery, delivery, delivery' mantra we see in the area this could be more likely to be significant than most.

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styxboa t1_isid25u wrote

What do you mean delivery delivery delivery mantra? Not familiar with the space

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TemetN t1_isiez70 wrote

This is kind of a what it says on the tin case, basically one of the biggest problems being tackled in this field is successfully targeting and integrating treatments. As a result, even if this method turns out to be problematic down the line, it has a better than average chance of being significant.

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ihateshadylandlords t1_isbjh0c wrote

Excited to see what therapies come up over the next century.

!RemindMe 10 years

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Rakshear t1_isbb8dv wrote

So could this cure eye issues? When can my asthma be fixed?

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mli t1_isbmaw8 wrote

Do anyone actually know someone who has had crispr-based therapy?

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MrDreamster t1_isc9ww8 wrote

That's exactly what I was wondering. I've been hearing about Crispr for I think more than 10 years, but I am yet to hear about Crispr being actually used as a treatment. Why is that ?

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Ezekiel_W OP t1_isd7i7p wrote

We need those 10 or so years for more research and development. Humans have had CRISPR used on them many times already, but it's still early days for human trials. Most of the good stuff with CRISPR probably won't start appearing until the late 2020s.

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-ZeroRelevance- t1_isdy95i wrote

It’s probably just that medical technologies take a long time to be approved.

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SWATSgradyBABY t1_isffgqs wrote

This has always been true. Increasingly we are able to use biological modeling in virtual space to simulate trials as we did with the COVID-19 vaccine. In that instance bringing the development time down from 5 to 10 years to one year.

Remember exponential not linear

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breloomislaifu t1_isdyvnp wrote

TLDR: drugs in a nutshell.

Its because we don't know what effects a drug will have until we actually inject it. You have to realize that our entire body is a diffusion prone liquid chamber of a billion moving parts but we need to deliver soluble drugs to a very specific target number of cogs. That's physically impossible btw.

So we end up having unknown side effects, and every drug has them. We just have to be persistent and select the ones that are effective at curing yet tolerable enough, but this process can take upwards to a decade in clinical trials.

In practice this means we have a decade long backlog of drugs that we think are promising but haven't had the time or resources to check. We'll get to testing CRISPR in maybe a few more years.

One more thing, as a scientist who has used CRISPR systems in cell cultures, its not that 'robust' yet. If I had to choose between successful CRISPR and fliiping a coin in a game of russian roulette, I'd still take the coin lol.

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AsuhoChinami t1_isdz6ld wrote

But... we are already testing CRISPR. I think the first human trials were 5 or 6 years ago.

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Baron_Samedi_ t1_isef1zr wrote

It takes about a generation to go from technological breakthrough to large scale deployment of these types of innovation.

There are a lot of nuts-and-bolts R&D, medical safety testing, manufacturing, supply, and logistics issues to consider when looking at how new discoveries will broadly impact society.

So, from the initial Crispr breakthrough to actually seeing the effects of this revolutionary tech, you are looking at 15 - 25 years for some of the most important innovations to be noticeable for those of us outside the laboratory.

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[deleted] t1_isccwqp wrote

[deleted]

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[deleted] t1_iscdz7p wrote

[deleted]

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kmtrp t1_isec6nl wrote

Blame the FDA and... realize biology is a fucking mess. Specially with novel therapeutic vectors. We've rushed before in clinical trials that have maimed and killed humans.

I remember one of those, guess what happened? The field was frozen for almost 10 years. Nobody wanted to put money or political face on and have the same thing happen again.

So it takes years and years of mountains of paperwork and money and tests and more paperwork to prove safety first and then efficacy. I'd rather do most of these by compassionate use, but... I'm not in charge.

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[deleted] t1_isd8s61 wrote

Big Pharma

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kmtrp t1_isebjuz wrote

I don't think you know about big pharma. They want these things by yesterday, because of money, you know? Always have but are heavily slowed down by the FDA's guidelines demanding all evidence in the world that this won't ever ever backfire in humans. This means more time and money spent performing safety preclinical and clinical trials and endless mountains of paperwork and years of back and forth with them.

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[deleted] t1_isf4209 wrote

Yeah, pharmaceutical companies are extremely eager to make themselves obsolete. You’re right. What was I thinking?

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[deleted] t1_isf4c50 wrote

Because of money, you know, fucktard?

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duffmanhb t1_iscbisv wrote

There are only a small amount of super expensive custom drugs available... It's probably not going to be until the end of the decade until we start seeing it more widespread.

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explicitlyimplied t1_iu9mxx3 wrote

Assuming crispr is involved there's only two marketable gene therapies rn. Supposed to be like 10 end of 23

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ZoomedAndDoomed t1_iscioqr wrote

GPT-3 summary:

The breakthrough discussed in this article is a new platform for gene editing that could inform the future application of a near-limitless library of CRISPR-based therapeutics. This breakthrough is significant because it provides a system to deliver the cargo required for generating the gene editing machine known as CRISPR-Cas9. This breakthrough works by transforming the Cas-9 protein into a spherical nucleic acid (SNA) and loading it with critical components as required to access a broad range of tissue and cell types, as well as the intracellular compartments required for gene editing. The article discusses how this breakthrough could help gene editing technology infiltrate cells and overcome a critical limitation of CRISPR.

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Ilunamie t1_isbygwj wrote

Genuine question out of curiousity: does this imply that muscular dystrophy could be treated better, and vice versa it could be used as a way to dope up for sportsman and body builders? I mean gene editting doesn't strike me as something that could be easily proven, or?

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Ezekiel_W OP t1_isg0t35 wrote

The short answer is yes. Eventually, as tech progresses and our knowledge base increases you could turn a bodybuilder into a zebra if you wanted.

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Ilunamie t1_isg13vz wrote

That implies that it would be possible that an ex girl of mine turns into a horse and I have to admit that I fucked her. Why you gotta scare me like that?

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WaycoKid1129 t1_iscqjc6 wrote

In a decade we may be talking about the eradication of a lot of genetic disease

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SuitableAd6672 t1_isg68fn wrote

The pipeline for distruttive treatments like these is much slower to reach the masses

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SteppenAxolotl t1_isbxhpw wrote

This could make it easier to design gene drives for humans. It would be the perfect birth control for unwanted populations after robot labor takes over the heavy lifting.

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No-Philosopher2573 t1_isexta3 wrote

Yep. Far more concerned about the future inequality to come from crispr thsn the benefits..

Big pharma- put massive effort to cure minor genetic defects from low to middle income famalies. OR

-super engineer billionares children for huge cost and take government funding to steralize unwanted populations.

I think option 2 is much more likely unfortunately.

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Ezekiel_W OP t1_isg15vl wrote

CRISPR is actually very cheap, you can order a kit online yourself if you really wanted to.

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No-Philosopher2573 t1_isg1q8r wrote

Yeah and effectively modify genes? You can order iron too its not economocal for the average person to create steel and manufacture products. CRISPR is the very intro to actually applying this at any scale

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r0cket-b0i t1_isdtjla wrote

To all of you who wonder it science never leaves the lab - medical takes longer than material science for example, but don't you all remember foldable displays being showcased at trade shows for like 4 years and we all thought "this never gonna go into co sumer product, it's vapor", and now we are at 4th gen consumer foldables and people aren't even surprised with those. Take Samsung flip and take it to a timeline 15 Years back - it looks and feels like a movie prop, no way it's real..

Medicine is the same we know it, in 1960, 1990 etc people were hearing about scientific concepts and those are now in the mass market from Lasik, to some Stem Cells therapies to HIV that used to be a death sentence similar to rare forms of cancer today, it not longer is....

Pace is a bit irritatingly slow compared to GPU progress and ability to simulate water in fps games (kidding) but it is also getting faster...

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[deleted] t1_isd506f wrote

Lemme guess “the researchers say it will still be years before the technique is available to humans. They hope to start clinical trials within the next 5-7 years.”

I genuinely love this science. I love that it got posted. I read thousands of pages on it. And I’ve become so bored with news articles about it.

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Black_RL t1_isgu2in wrote

Good, good, fix the code, fix the problem.

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arebya t1_it7nm6t wrote

!RemindMe 5 years

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