Interestingly enough Ketamine actually does have activity at 5-HT2 receptors.

As far as I'm aware 2-bromo-LSD doesn't have antidepressant efficacy. There are now a few substances that labs believe are non-psychoactive and retain antidepressant efficacy, but they base this off mouse head twitch response and they have yet to be validated in humans.

Interesting, might also explain why SSRIs are known to blunt psychedelic effects.

This also seems to suggest 2A agonism is at least partially related to neuroplastic effects, which would definitely hamper efforts in creating "trip free" derivatives.

I wonder how this relates to 5-HT2A-mGlu2 heterodimers.

Unfortunately people like Stamets are more interested in fantasy and selling hype than the scientific method. Still a very interesting area of research.

Nothing wrong with pointing out the finding is commonsensical.

Having read the article, his comment still holds.

I don't know the depths of his work beyond arguing for metaphysical idealism, but I research psychedelic drugs and his argument here is completely wrong.

> No, I am not kidding. Blue represents decreased brain activity. I didn’t create this figure; I downloaded it from the paper in question. Here is the direct link if you want to check it. Contrary to what the researchers claim in their reply, the findings in this paper weren’t “only modest increases in brain blood flow confined to the visual cortex”; they were of widespread decreases in activity throughout the brain.

If you actually look at the figure you see reductions in alpha activity, which would indicate increased brain activity as alpha rhythms are suppressive.

Not citing a paper here but quick copy/paste from wikipedia:

> Alpha waves are reduced with open eyes and sleep, while they are enhanced during drowsiness. Historically, they were thought to represent the activity of the visual cortex in an idle state. More recent papers have argued that they inhibit areas of the cortex not in use, or alternatively that they play an active role in network coordination and communication.

Kastrup ignores this and just states blue = less activity. He also proceeded to die on this hill and continue to try to engage in debate with actual scientists that understand EEG.

If he's this arrogant about fields he's uneducated about I'm not so interested in his philosophy.

I wonder if this can be used for cognitive assessment, it would be interesting to see if it's disrupted in depression or neurodegenerative disease models.