Mounta1nK1ng
Mounta1nK1ng t1_j9cv3cm wrote
Reply to [I ate] Some cookies by the_humeister
I would eat those cookies.
Mounta1nK1ng t1_j09fevc wrote
Reply to comment by Pechumes in Oregon governor commutes all 17 of state's death sentences by Slavic_Dusa
And he would have been released in 12 years anyway, and we would not have gotten anything for his release. This way we got an American citizen back.
He only had a 25 year sentence and was about halfway through it.
Mounta1nK1ng t1_iy5ighr wrote
Reply to Marshall Mathers, or Eminem, in his 1989 yearbook photo at Lincoln High School. by TetraCGT
This looks like a page from my high school yearbook. Made me double take.
Mounta1nK1ng t1_iy5ht0f wrote
Reply to comment by CrimsonToker707 in From a restaurant in Malaysia by QiamOnline
Hence the use of the word gullible.
Mounta1nK1ng t1_ivpj6t8 wrote
Reply to comment by TheAero1221 in Experimental “FLASH” cancer treatment aces first human trial by tonymmorley
You are correct that you're totally wrong. We don't vary the angles over time, we just select a large number of angles. Basic idea, if you shot from just one angle, all the tissue on the entrance path would be getting more dose than the tumor. If you shot through 10 different angles for a single treatment, than each entrance path through normal tissue would be getting only 10% of the dose, but where they all overlap at the tumor, it's getting 100% of the dose. This treatment with the 10 angles (usually actually only 5, 7, or 9 for static IMRT) would be given every day for 5-8 weeks in conventional radiotherapy using those same angles for each daily treatment.
The evolution of this is having the gantry rotate constantly through the treatment, varying the dose rate and shape of the beam during the rotation to avoid dose to especially sensitive tissues, while making sure you completely cover the target. So instead of 10 (or 5 or 7) discrete angles you have the maximal spread of the entrance dose. It's called VMAT, volumetric modulated arc therapy.
Mounta1nK1ng t1_ivphc1n wrote
Reply to comment by 17FeretsAndaPelican in Experimental “FLASH” cancer treatment aces first human trial by tonymmorley
Amount of people dying of cancer went down despite people continuing with behavior that increases cancer like smoking, being overweight, not eating enough fruits and vegetables, and eating too much processed meat.
We're better at detecting it now, and better at treating it.
Also people overly hype mouse trials to get funding, but humans are not mice. The results frequently don't translate well.
Mounta1nK1ng t1_ivpfm3h wrote
Reply to comment by st4nkyFatTirebluntz in Experimental “FLASH” cancer treatment aces first human trial by tonymmorley
You are correct. The whole point is delivering it all at once so you get the FLASH effect. Different radiobiological mechanism than traditional fractionated radiotherapy.
Mounta1nK1ng t1_ivpfdpt wrote
Reply to comment by brockclarke in Experimental “FLASH” cancer treatment aces first human trial by tonymmorley
Dose rate, and all delivered in a single pulse.
Mounta1nK1ng t1_ivpcbmz wrote
Reply to comment by ptjunkie in Experimental “FLASH” cancer treatment aces first human trial by tonymmorley
The FLASH studies have shown the lower side effects by using a single pulse, so the idea when putting this into clinical practice would be a single shot. Obviously no fractionation, as this isn't relying on the 5 R's. It's relying on a transient radiation-induced hypoxia that affects tumor cells more as they're already hypoxic.
For clinical treatment they would be looking at multiple treatment head gantries so the tumor could be shot from multiple angles at once in a single pulse so that you get the benefit of the FLASH effect that this treatment relies on.
Mounta1nK1ng t1_ivpaqay wrote
Reply to comment by ptjunkie in Experimental “FLASH” cancer treatment aces first human trial by tonymmorley
I was looking in the article to see whether it was a photon or proton based system, since you can do FLASH with both, but I must have missed it. I understand it's not intended for limbs. We already do palliative treatments in one fraction with little to no side effects.
Mounta1nK1ng t1_ivlmdgp wrote
Reply to comment by PartyPineapples714 in Experimental “FLASH” cancer treatment aces first human trial by tonymmorley
Mounta1nK1ng t1_ivlmclz wrote
This is interesting, but we don't usually see any side effects when treating bone mets in the limbs as the surrounding tissue isn't all that radiosensitive. The next study will tell us a lot more.
Mounta1nK1ng t1_j9g39fj wrote
Reply to Unlike most mammals, female naked mole rats develop new eggs throughout their entire lives – a finding that could lead to improvements in human infertility research. by chrisdh79
Why my baby look like a naked mole rat?