Mounta1nK1ng

Mounta1nK1ng t1_ivpj6t8 wrote

You are correct that you're totally wrong. We don't vary the angles over time, we just select a large number of angles. Basic idea, if you shot from just one angle, all the tissue on the entrance path would be getting more dose than the tumor. If you shot through 10 different angles for a single treatment, than each entrance path through normal tissue would be getting only 10% of the dose, but where they all overlap at the tumor, it's getting 100% of the dose. This treatment with the 10 angles (usually actually only 5, 7, or 9 for static IMRT) would be given every day for 5-8 weeks in conventional radiotherapy using those same angles for each daily treatment.

The evolution of this is having the gantry rotate constantly through the treatment, varying the dose rate and shape of the beam during the rotation to avoid dose to especially sensitive tissues, while making sure you completely cover the target. So instead of 10 (or 5 or 7) discrete angles you have the maximal spread of the entrance dose. It's called VMAT, volumetric modulated arc therapy.

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Mounta1nK1ng t1_ivphc1n wrote

Amount of people dying of cancer went down despite people continuing with behavior that increases cancer like smoking, being overweight, not eating enough fruits and vegetables, and eating too much processed meat.

We're better at detecting it now, and better at treating it.

Also people overly hype mouse trials to get funding, but humans are not mice. The results frequently don't translate well.

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Mounta1nK1ng t1_ivpcbmz wrote

The FLASH studies have shown the lower side effects by using a single pulse, so the idea when putting this into clinical practice would be a single shot. Obviously no fractionation, as this isn't relying on the 5 R's. It's relying on a transient radiation-induced hypoxia that affects tumor cells more as they're already hypoxic.

For clinical treatment they would be looking at multiple treatment head gantries so the tumor could be shot from multiple angles at once in a single pulse so that you get the benefit of the FLASH effect that this treatment relies on.

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