gerundive

gerundive t1_j71v48u wrote

"You do not settle whether an argument is justified by merely showing that it is of some use. The distinction is not between useful and useless experiments but between barbarous and civilized behaviour. Vivisection is a social evil because if it advances human knowledge, it does so at the expense of human character."

  • George Bernard Shaw (1856-1950)
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gerundive t1_j6yaj7m wrote

I was curious how animals such as rats, dogs, monkeys etc might be given heart attacks, and found the following, which may be of interest to others who are similarly curious.

"Myocardial infarctions (MIs) in rats were originally induced by the sequential administration of subcutaneous isoproterenol causing diffuse myocardial necrosis. Subsequent investigators used an electrocautery technique applied to the epicardial surface to induce small, focal infarctions. Soon thereafter, Pfeffer et al developed the rat coronary ligation model that became perhaps the most widely used heart failure and MI model in the decades to follow."

Apparently transgenic animals can also be used, bred to carry mutated genes so that they develop hypertension, hypertrophy and subsequent heart failure.

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gerundive t1_itimg2k wrote

very interesting (and for me very relevant) -- i have long argued that people who find it difficult to read sheet music are neither lazy nor stupid (which used to be the common themes of posts on this issue from guitarists who could read sheet music), but instead most likely have a form of dyslexia

similarly my argument with music publishing companies that refuse to provide tab accompaniment to sheet is that they are discriminating against a sector of the public by preventing them having access to music that they have made available to non-dyslexic musicians

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