From the article

Patients taking Keytruda for advanced melanoma were less likely to die, or have the skin cancer reoccur, if they also had the jab, mRNA-4157/V940, Moderna and MSD said.
The findings, in 157 patients, have not yet been scrutinised by independent experts or regulators.
More trials will be needed to check how effective the treatment might be.
Moderna's chief medical officer Paul Burton said: "This is a significant finding. It's the first randomised-trial testing of an mRNA therapeutic in cancer patients.
"It's shown a 44% relative reduction in the risk of dying of cancer or having your cancer progress. That's an important finding and I think it has the potential to be a new paradigm in the treatment of cancer patients."

Tailormade to match each patient's cancer, the vaccine is very expensive to make - although, the company has not named a price.
Prof Alan Melcher from The Institute of Cancer Research said: "There's no question, this is very exciting. These results show the feasibility of making and delivering personalised vaccines to treat cancer, and that the vaccine can add benefit to current treatments.
"These results establish the principle that this complex technology is doable."
Consultant colorectal surgeon at the University of Birmingham Mr Andrew Beggs said: "Although early data, it is very encouraging that this is a likely effective treatment option in the future.
"This advance is likely to have important implications for metastatic cancer patients in the future and opens a new therapeutic avenue for these patients."
Dr Sam Godfrey from Cancer Research UK, said: "There is unlikely to be a single cure for cancer and we must focus on ways to tailor treatment for patients. These results are grounds for optimism that the science which helped get us out of the pandemic could add another powerful treatment option for cancer in the future."

The following submission statement was provided by /u/Phoenix5869:

From the article

Patients taking Keytruda for advanced melanoma were less likely to die, or have the skin cancer reoccur, if they also had the jab, mRNA-4157/V940, Moderna and MSD said.
The findings, in 157 patients, have not yet been scrutinised by independent experts or regulators.
More trials will be needed to check how effective the treatment might be.
Moderna's chief medical officer Paul Burton said: "This is a significant finding. It's the first randomised-trial testing of an mRNA therapeutic in cancer patients.
"It's shown a 44% relative reduction in the risk of dying of cancer or having your cancer progress. That's an important finding and I think it has the potential to be a new paradigm in the treatment of cancer patients."

Tailormade to match each patient's cancer, the vaccine is very expensive to make - although, the company has not named a price.
Prof Alan Melcher from The Institute of Cancer Research said: "There's no question, this is very exciting. These results show the feasibility of making and delivering personalised vaccines to treat cancer, and that the vaccine can add benefit to current treatments.
"These results establish the principle that this complex technology is doable."
Consultant colorectal surgeon at the University of Birmingham Mr Andrew Beggs said: "Although early data, it is very encouraging that this is a likely effective treatment option in the future.
"This advance is likely to have important implications for metastatic cancer patients in the future and opens a new therapeutic avenue for these patients."
Dr Sam Godfrey from Cancer Research UK, said: "There is unlikely to be a single cure for cancer and we must focus on ways to tailor treatment for patients. These results are grounds for optimism that the science which helped get us out of the pandemic could add another powerful treatment option for cancer in the future."

Please reply to OP's comment here: https://old.reddit.com/r/Futurology/comments/10s80gd/cancer_mrna_vaccine_completes_pivotal_trial/j6zze8f/

Who will be able to afford the customized treatment?

My thoughts aswell, but if it's available that's better than not having it

I dunno. To me, I can't think of a worse feeling than knowing there is a cure for my mother's disease, but because we aren't rich, she will be forced to die from it rather than being saved. That's torturous.

Just like everything else, it starts out ridiculously expensive and then comes down over time as the capacity is built out and it becomes more common. Give it some time... and it will be within everyone's reach.

So you’d rather no one has it?

How long will it take before the antivaxx community demonizes this mRNA solution and others like it?

Wouldn't insurance pay?

Oh, no doubt already started.

To those anti-science, lead suckling, nimrods, mRNA might as well be the word that summons bees to come crawling from their nipple. They're freaking terrified of "that unnatural stuff."

It's so freaking stupid. Hint: your body is full of that stuff. Messenger RNA is a big part of how your body communicates on the genetic level.

I'm pretty sure that's not what they meant.

Yes and no. I know a lot of antivaxxers (ex-military…) and they’re surprisingly cool with the mRNA cancer vaccine.

Then you tell them we need to implement mandatory EBV/CMV vaccination and they lose their minds.

It should be a law…if you wouldn’t take the vaccine for Rona….then you don’t get this one

It should be a law…if you wouldn’t take the vaccine for Rona….then you don’t get this one

It should be a law…if you wouldn’t take the vaccine for Rona….then you don’t get this one

Biontech has failed more than 10 years to pass safety standards for such a medicin. Now after fast track approving the corona vax they can push this one, too. The pharma lobby wins, people die.

I predict a large percentage would very quietly/sheepishly (lol🐑🐑🐑!! /s) accept the cancer vaccine if it were to help them not die.

I don't know about you, but I was in the military long enough ago to remember the initial anthrax vaccines that were still being developed when they were made mandatory.

It's one thing to be reluctant about something because of ignorance and/or simply not knowing WTF you're talking about, but it's quite a bit different when someone has a track record for shifty/shady shit.

While pushing conspiracy theories that a cure for cancer existed since the 70s but has been silenced by them

Yeah I’m Aussie, we mangled some people with experimental malaria stuff. East Timor. I get it.

Still, this ain’t that. mRNA had a huge rollout, and the stats supports vaccination. Benefit outweighs the danger.

What do you mean?

That’s a very unkind sentiment. I wouldn’t tempt the fates like that.

I hate how this is exactly the first thing I thought of as well.

Instead of being excited for this news and hopeful for the future, these anti vaxx morons are the first thing that popped into my head.

People who don't live in the US.

32 out of 33 developed countries have National Healthcare. The US is the only one that doesn't.

[removed]

I suppose there is a difference in ones acceptance of eg. risk or unknown if the alternative is certain death as opposed to flu.

Isn't that basically the same thing as limiting it to the super wealthy?

44%'s not bad for something with negligible(?) side-effects, compared to chemo.

The German Anti Vax Community already started to bash the Vaccine because of mRNA, but they lost their mind anyways

For us in the military it isn't that we are necessarily anti-vaccine. We are anti injecting us with experimental shit that we have no choice over due to military regulation. I have no problem with vaccines in general but will wait for peer reviewed studies over long periods of time before I put experimental medicine of any sort in my body once I leave the military

In my experience, the military people that say “it’s not safe” when it’s a vaccine, are the ones that do the most dumb shit outside of work. And inside of work.

[deleted]

They mean "lead paint is so delicious, why is it banned?"

[removed]

Counterpoint: fuck those people.

I will take a vaccine for cancer.

Exactly. Melanoma's not contagious. If someone doesn't want to take a vaccine of it, hey, it's their life.

[removed]

How many lives were saved by the vaccine? Have you looked?

The new rallying cry will be vaccines give you cancer

Seriously now...

They clearly have been warped by the flouride in the water over time

​

/s

Then they should just get the Johnson and Johnson which doesn't use the mRNA

That seems like a problem that will fix itself over time though right? If the rational people go get the vaccine and don't get cancer and the antivaxxers die at a greater rate... Eventually that evidence will be irrefutable and the norm will just be go get your fucking shots. Or the antivax idea will succumb to attrition over a long enough timeframe. Either way I'm gonna get a cancer vaccine.

National Healthcare systems often don't cover highly specialized treatment and research medicine. It's not even that they won't pay for it; they often just straight up don't offer it.

No, because if the technology exists it usually becomes available to the less wealthy over time as newer technology replaces it.

It's not ideal or fair, but if I had the choice between getting a cure 10 years later or not getting a cure at all, I'd opt for the later.

I was skeptical of the covid vaccine when I first heard about it because I didn't understand how it came about so fast when vaccines up until then took years/decades to develop and test. As I learned more I felt more comfortable in the experts recommendations to get the vaccine and I was in line the first day it was publicly available.

It's okay to be skeptical of something at first take IMO but holding on to skepticism in the face of insurmountable evidence and expert guidance is foolish.

[deleted]

You mean further than it already is? Because covid vaccine bad, chip, magnetic skin, mind control (whatever that is, I dared not to dwelve deep).

Wasn’t that flour? /s

Except when it's not, which is the problem. Adding social pressure doesn't fix the trust issues, it makes them worse.

Half my friends and family are in the medical field, which isn't to say my position is magically correct, but that I'm not exactly ignorant of how things actually work either. To be more precise, I'm not a "but muh mercuryz!" clown or a "Fire doesn't melt steel!" loon.

I have zero problem with "Shit was hitting the fan, so we had to make something work," but I do have problems with people who will never pay the price for their decisions that also inherenty have conflicts of interest and a long history of corruption along with poor decision-making (ie. Politicians) claiming exigent circumstances to justify telling me I can't make my own choices. I spent a quarter of my life in the military, another good chunk working for the government in some form or fashion before becoming a physicist, and I grew up in a state with a reputation for corruption and government overeach. My distrust doesn't come from ignorance, it's based in decades of personal experience.

Hell, I hope mRNA tech takes off and it proves out, precisely because of the things it makes possible, but I'm also perfectly fine waiting for the kinks to get ironed out. The FDA has a pretty long track record of coming back 5-15 years later with, "So that thing we said was safe? Yeah, uh, sorry about that..."

The difference here being that unlike the COVID vaccine or vaccines for other transmittable diseases refusing a cancer vaccine will only affect them as far as health is concerned. So let them refuse it. Natural selection.

Who knows those idiots probably won’t even know aboit it! They don’t like to do real research! They say the mRNA vax genetically modifies you, yet it is not true genetic modification. I am genetically modified and it was done by my cells being removed from my body via aphresis and sent to a specialized lab of whic there are 1-2 in the country, and each was individually genetically altered before being put back in my body. This melted my terminal stage IV cancer in four major organs away in a week. You don’t see them crying about CarT cell therapy though which is real genetic modification. They don’t even knkw about it and likely won’t know or care what the cancer conmunity is doing. They just like to find things that suit their need for complaint! They probably wouldn’t want to lokk bad for trying to take treatment away from cancer patients if they did hear of it, so it wouldn’t serve their interest to cry about it. They’ll probably ignore this life saving texhnology and continue to freak about the covid vax.

Everything around epidemiology is an estimate, and outcomes have to be measured at the population level due to variance between individuals, which is why anecdotes never qualify as data. You can certainly compare populations who have been vaxxed vs those how have not to build mortality and morbidity models. The issues is the completeness of the variables around each member of both groups, which is the core data collection issue of any population level medical study around humans.

This is easier to do and more reliable than you are indicating when done at the population level. Yes, I have done vaccine efficacy research in the past when I doing systems work in vaccine registries. I have built statistical models and still do. My last gig before my current job was building algorithms around pathogen detection.

[deleted]

Tell that to my dead friend who died right after taking the covid vaccine

It's not hard to get statistics on how many people were saved by the vaccine. You just look at what percentage of people who die from the disease who didn't get the vaccine compared to the percentage of people who die from the disease who did get the vaccine and apply the difference to the people who got the disease with the vaccine.

In a completely controlled environment, sure it would be that easy. Unfortunately, we don't live in such an environment.

There are other variables to account for, such as lifestyle differences between people who do or don't get vaccinated. What proves that the same people that would opt to get vaccinated don't have better hygiene habits, contributing to a lower mortality rate?

This isn't me trying to say that vaccines don't work. Far from it. It's me saying that looking at efficacy takes more critical thinking than just googling a number.

We don't need a controlled environment to get reliable statistics like that. You're talking about hundreds of thousands or even millions of people.

[removed]

[deleted]

I printed out a sheet and posted it at my work. It was from the CDC and explained how mRNA vaccines don’t change your DNA. Your DNA is in the nucleus of cells and the vaccine doesn’t go in there. I had to do this because of all the moronic conversations i overheard at my work.

_very expensive_

How long before only the 1% can afford life extension and disease immunity?

Like dying of cancer will be a poor person problem (i.e. you're worth less than $10mm)

Top link in a google search:

https://www.commonwealthfund.org/blog/2022/two-years-covid-vaccines-prevented-millions-deaths-hospitalizations

They already did! Remember Covid?

Their username checks out.

Bro they had „reasons“ against every Vaccine haha

[removed]

I strongly support them not taking any vaccines.

I've seen "I am Legend", Cancer vaccine bad, /s

Compared to chemo, yes, but mostly compared to death or progression as a result.

Where have you been? mRNA tech has already become a boogeyman that they have been crowing about since the first COVID vaccines

[removed]

They probably already are.

[removed]

As a guy that has leukemia, fuck these people.

I understand the same.

Here is an article stating it: "The Moderna/Merck vaccine is personalized, meaning the mRNA sequences it delivers are tailored to each patient. And it is intended to prevent recurrence of cancer rather than prevent cancer in the first place. But in other ways, the jab is similar to mRNA vaccines for COVID-19." Source: https://cen.acs.org/pharmaceuticals/vaccines/ModernaMerck-cancer-vaccine-shows-promise/100/web/2022/12

Shhh don't bring logic and reasoning into a blanket statement thread!! /s

Wait till India sells it for $10

Depends. I think (well, hope) that it'd be a smaller contingent of people against this than Covid vaccines. I think there was a rational fear among many that the Covid vaccines hadn't been tested long term (thalidomide is still a living memory for many), and combined with feeling like they were being forced to take it, many people became quite anxious and susceptible to people pushing conspiratorial narratives. A cancer "vaccine" is never going to be mandatory and there's no rush for people to take it since this isn't a preventative. Makes it a harder sell for people pushing the dumb idea that it's a mind control tracking chip that'll turn your kids gay or whatever bullshit they were spewing.

All depends on the math. If this is cheaper then longterm care. Anyone with insurance

Proven corporations and US Govy has pushed heavy into areas that cause rapid cancer in America, those Same people come out with experimental "treatment" for the problem they created...

No one bats an eye...

funny how this is seen as dissent

Dying en masse from covid and cancer is owning the libs so hard

I didn’t take the vaccine, but primarily because I wasn’t high risk. I think there’s quite a lot of difference between trying to fight cancer than taking a vaccine for Covid and I’d imagine folks in that position would likely opt in.

this is the strangest part of the equation to me

The flu? Wasn't the antivax push primarily over COVID 19? You know, the deadliest pandemic in US history...

Yeah, one major difference being that the COVID vaccine's effectiveness was contingent on herd immunity...

>Or maybe people will look at each treatment separately & consider the benefits, risks & circumstances

Why would they do that? they didn't weigh the options with COVID.... They just took up the anti-establishment, conspiratorial bandwagon and followed suit as blindly as anyone else.

Only instead of following the recommendations of the world's leading experts, they followed fringe researchers and conmen populists.

Probably, but a large percentage is also going to vehemently oppose the vaccine based on intuition alone... Just like with covid.

I don't think conspiratorial neurosis just goes away on its own.

The more you ignore it, the more you silence it, the stronger the sentiment grows.

Human genetic modification is going to become so commonplace in the future. There are just so many amazing applications for it.

I've heard people talk about how the vaccines magnetize your body....

I completely agree! It’s definetly in our future! Maybe once more and more diseases are cured on account of it, then people will be more accepting. I have come across many people online who do not even realieze humans are getting genetically modified now.

When the treatment enters something like a consumer level market, though... Many, many Americans will simply be priced out due to being underinsured.

Call me naïve, but the whole global conspiracy thing seems really juvenile. It couldn't possibly be that simple....

Calm down, we're deep into a reddit comment section.

Honestly I agree. If you intentionally avoided the mRNA vaccine because you wanted to virtue signal or were simply too stupid, then maybe you should be held to your bullshit.

mRNA was too wacky, dangerous, and mind controlling during the pandemic, why should we tolerate a sudden, selfish change of heart?

[removed]

>Never said you didn't. I simply said that asking people to look up a hard number on lives saved isn't realistic.

Oh please dude. Your bias is obvious. You seriously skipped over that brain dead comment to start a line of pedantry...

Agreed! I just wonder with the Covid vaccine being a form of preventative action/community duty…mixed with the anti-vax rhetoric of “it’s just the flu!” vs being diagnosed with something potentially fatal and having something tailored to potentially fix it…there a bit more immediate personal urgency.

But like you said, many will still refuse it, based solely on the mRNA tag alone.

Anywho. I’m stoked on the potential of this tailored vaccine!

>What are you talking about? 80% of the USAs population took the vaccine, 70% of the entire world population took the vaccine.

We're talking about antivaxers, don't drag the rest of humanity along in an attempt to appear more rational than you are.

20-30% is a significant amount. The apprehension to get the vaccine was significantly more pronounced at the height of the pandemic as well.

It's also worth noting that those figures you're referring to also include partial vaccination.

>And for what? So that {x} pharma companies made record profits for a 'vaccine' that didn't provide immunity or stop transmission.

What?

Wait... Are you going to do that thing where you say that the vaccine doesn't give you 100% immunity and that means big pharma is lying to you? Boring...

The vaccine has been shown to be extremely effective at preventing and mitigating the infection.

It's not 100%, no. I have no idea why anyone would think it is 100%, as that's not the case for literally any medical treatment in the history of all medical science.

Check out something like the movie dark waters, been going on for over a century.

>there a bit more immediate personal urgency.

You might be right. At the very least, they probably believe that cancer is dangerous. Which is... Something lol.

It could make people go the other way actually. If successful on Cancer plus conspiracy theories aging out overtime maybe the pengilum will swing back. If it was me I would have the face of this drug be an independent scientIst. Leaving no possible monitary, company affiliation, spouse connection for imaginations to run wild. Not that I have it all my damn self.

[removed]

antivax discussion aside, this is how I am legend started so get your uv lamps people

Well you'll have to forgive me. Every time I argue with someone who is "skeptic" they point me to a ridiculous documentary, or some schizoid manifesto.

I haven't personally delved into the corruption and conspiracy surrounding pharma companies. I'm sure there is corruption, and I'm sure people have suffered for the sake of profits, but I'm hesitant to buy into a grand conspiracy (not sure if that's what you're suggesting).

[removed]

[removed]

Same idiots run to the hospital for chemotherapy when they’re dying

i am not getting it. never.

you go get it 😂

Where did you do your graduate work to develop the background necessary to evaluate the work of hundreds if not thousands of PhDs with whom you disagree? I did mine at a big ten university. My first science job was sequencing a bacteriophage now used in gene therapy. However, I am sure your “critical thinking” will allow you to overcome any gaps in your education and experience.

If you were on your deathbed with only days to live, you wouldn't get it?

Sure about that?

couple days better than zero days though

Yep, no one needs to push it to keep others around them healthy.

But they shouldn't burden others with healthcare costs for something easily preventable.

As far as I’m concerned if you refuse the vaccine and need treatment you can pay for it out of pocket. I wouldn’t be surprised if insurance companies in countries with privatized healthcare will refuse to cover any costs associated with the treatment for someone who refused the vaccine as well.

Okay cool, so I can expect to stop hearing about people dying of cancer then, right?

I'm super curious to see how anti vaxxers react to the exact same technology as COVID vaccines, but for friggen cancer.

This is one of the few good things to come from covid. the accelerated support mRNA technology received means we will have vaccines for cancer, HIV, alzheimers, etc at some point, hopefully in the near future

“Tolerate”??? Who are you to decide someone else’s heath care? I’m new to Reddit, came for the cancer support where we say everyone has to decide their own journey, and here you people are thinking you should be able to “down vote” people to die because you don’t agree with their healthcare choices. I mean, seriously. Who thinks like this? What kind of mean spirited people are you? How ugly.

I’ll stick with my cancer friends, screw this garbage.

Yep this and CRISPR are going to make science fiction medical advances common place. Hope I live long enough to see it get out of the trial phase.

>Who are you to decide someone else’s heath care?

Some guy on Reddit.

>you should be able to “down vote” people to die

If only

>Who thinks like this? What kind of mean spirited people are you? How ugly.

Lol, you should really lighten up. I thought people with cancer were supposed to be chill. What gives?

Gaslighting cancer patients - aren’t you edgy?

Yeah they can’t spread cancer by refusing the vaccine.

"Gaslighting". And just when I thought you couldn't possibly be more dramatic...

You sure you got cancer at all? Maybe it's just a cold.

Are you feeling gaslit?

Stage 3C ovarian cancer, diagnosed right before Christmas. You think you’re being cute but you’re really awful. Reporting and blocking.

>I don't think conspiratorial neurosis just goes away on its own.

It goes away if the person with conspiratorial neurosis dies of cancer because they refused to get the cancer vaccine, though.