barbzilla1

barbzilla1 t1_jeh2h6l wrote

Reply to comment by AAA515 in What is known about pain enhancement? For instance, are there drugs that are the opposite of analgesics? If so, what are they and how do they work with neurons/neurotransmitters? by DollyPartWithOn

They set the temperature of a scientific hotplate to the level painful but not physically damaging to lab mice, then administer a combo of whatever drug they are testing and a control/placebo to various mice, they then place said mice in said hotplate and time the pain reaction. The mice usually get used for between a week and a month then are either dissected or disposed of.

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barbzilla1 t1_jeglpd2 wrote

Reply to comment by International_Bet_91 in What is known about pain enhancement? For instance, are there drugs that are the opposite of analgesics? If so, what are they and how do they work with neurons/neurotransmitters? by DollyPartWithOn

When they are speaking of pain meds here they are testing responsiveness to said pain using the hotplate test with mice. While it has an analgesic property as it brings relief, it is not lessening nerve signals as the topic was about. I realize I'm using layman's terminology, but there are many plants with much better allergies and effects as far as reducing nerve signal. Such as Tylenol and aspirin, so honestly the gold standard is cone snail toxin but most people are prescribed either gabapentin or Lyrica.

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barbzilla1 t1_jeg5ch0 wrote

Reply to comment by ilovemybrownies in What is known about pain enhancement? For instance, are there drugs that are the opposite of analgesics? If so, what are they and how do they work with neurons/neurotransmitters? by DollyPartWithOn

That's primarily because opiates themselves have very weak analgesic properties. This is why most prescription opiates come with acetaminophen or APAP, as it is one of the most effective analgesics. What the opiates do however, is dump a ton of dopamine on your neurotransmitters causing you to care less about the pain that you were already in. For some reason after perceiving less pain you'll actually start to feel less pain too, and I don't just mean on the short term there is an actual correlation between accepting the pain and lessening the pain

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barbzilla1 t1_j3gbp5a wrote

Reply to [Discussion] I'm 23 with a lot of Fs on my college transcript and very little to show from the past 5 years... my goal is to be a doctor and I'm not sure I could be farther from achieving that goal. by richTING13

Medical schools extremely competitive to get into, so unless you have Rich parents those college after pretty much going to exclude you. That said there's nothing saying you couldn't do a four year RN program and then cross over into a physician's assistant or nurse practitioner

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