randompersonx
randompersonx t1_j8buolb wrote
Reply to comment by DeSquare in Metformin regulates myoblast differentiation through an AMPK-dependent mechanism (Feb 2023) by basmwklz
What’s that date cutoff based on?
randompersonx t1_j88fauu wrote
Reply to comment by crazyhadron in Metformin regulates myoblast differentiation through an AMPK-dependent mechanism (Feb 2023) by basmwklz
Keep track of AST/ALT over time. Part of how Metformin works is it blocks gluconeogenesis which is basically the process of the liver producing glucose. Most likely if you are relatively low body fat % and have hopefully zero (or very low) visceral body fat, this may not matter so much…
But I’d imagine the higher risk comes into play if you have a NAFLD already.
And yes, you are right about kidney issues, too. My dad was on Metformin for a few years and was eventually diagnosed with some mild kidney issues that were believed to be caused by it, and his medications were changed. That said, my dad is overweight and inactive and diabetic… so his case will be very different if you are living a healthy lifestyle.
randompersonx t1_j8899t2 wrote
Reply to comment by crazyhadron in Metformin regulates myoblast differentiation through an AMPK-dependent mechanism (Feb 2023) by basmwklz
When you say benefits, do you mean the on-label diabetes treatment, or off label as a diet aid or longevity drug?
I looked into it as a non-diabetic, and the risk of liver damage seemed too high for me to consider it. Sure it makes sense for people who need it, but I’m unconvinced it is always going to enhance longevity… and it certainly isn’t strictly necessary to lose fat.
randompersonx t1_j886d6s wrote
Reply to comment by scutiger- in How do deal with an early sighting of bedbugs? by CamDaMan100
My wife and I got bit by bedbugs in a hotel once. Luggage lived in the garage (far from the bedrooms) for months. Laptops and other electronics went in the freezer for a few days. Clothes went through high heat wash regardless of if it was “safe” or not.
Fortunately we didn’t bring any into our house… but I was still paranoid for months after just one night or bedbug bites.
randompersonx t1_j5gz1vm wrote
Reply to comment by onetwentyeight in Diets with low potassium are associated with kidney injuries and a culprit in cardiovascular disease by giuliomagnifico
Potato, po-ta-to.
There are also some foods which would probably meet the definition of unprocessed for many people which wouldn’t necessarily be considered clean by most people following they sort of diet … eg: fresh squeezed apple juice.
randompersonx t1_j5gw289 wrote
Reply to comment by onetwentyeight in Diets with low potassium are associated with kidney injuries and a culprit in cardiovascular disease by giuliomagnifico
Clean = no processed foods. No man made chemicals. No seed oils. Oils that can be extracted by cold expeller pressing or churning are okay.
Everything you eat is as close to the way it was when it was living at the time you eat it. Obviously cooking is okay, but best to bake instead of fry when practical.
randompersonx t1_j5gfq1x wrote
Reply to comment by Fleinsuppe in Diets with low potassium are associated with kidney injuries and a culprit in cardiovascular disease by giuliomagnifico
I agree, but also want to point out that if you are trying to have a very clean diet, it’s very easy to end up with low blood sodium. I did this.
I switched to a diet of only one meal a day, and only these ingredients:
Proteins: steak, fish, chicken, shrimp, oysters, eggs, bacon
Veggies: lettuce, cabbage, tomato (yes I know, technically a fruit including a few others on this list, but we eat them as vegetables and they are low sugar), peppers, onion, olives, avocado, broccoli, cauliflower, broccolini.
Oils: extra virgin olive oil, organic virgin coconut oil, organic virgin avocado oil, grass fed butter.
Once I hit my goal weight I will add back whole milk, plain yogurt, kefir, cottage cheese… I’m just trying to avoid the carbs for now.
I’ve been really enjoying the diet, it’s been very easy to follow and I’m losing a ton of weight very fast and retaining muscle…. But I had a blood test and came by low blood sodium and had to start putting salt on everything to correct it.
The amount of salt in processed food and restaurant food is crazy high… and as soon as you start only having unprocessed food, it’s very very easy to end up low sodium.
randompersonx t1_j4pzksv wrote
Reply to comment by sirunknownlandon in New suicide hotline 3 digit 988 receiving half a million more calls texts, and chats since starting than prior 10 digit number by Inkling2424
Years ago I tried calling one during a rough time. I was on hold for over an hour before getting dropped with an automated message to try calling back later.
randompersonx t1_j1gzqcp wrote
Reply to LPT: Buy two snow shovels by EfficiencyArchitect
Any suggestions on where to buy a snow shovel? I checked all the supermarkets and home goods stores in Orlando, and nobody seems to have them.
randompersonx t1_jdc194c wrote
Reply to comment by Elfere in Barbie maker celebrates ‘power of representation’ with scoliosis doll by wol_75
I was diagnosed with scoliosis last year at age 39. When looking at an x ray from a deca scan, it’s very obvious to see the twists in the spine and the uneven hips…
But when standing up right and wearing clothes, 99.9% of people would never notice it, and would say it’s in my head if I mentioned it.
I can absolutely feel the twist and the effects of it, especially when lying on my side in bed, or lifting weights…
Anyway, having scoliosis doesn’t always mean that you have a very obvious case… and unfortunately for me, because it wasn’t obvious, it didn’t get diagnosed until age 39, when it was far to late to do anything to correct it.