Comments
thebestoflimes t1_jcilntl wrote
- looks down at notepad, scratches out “rich” and writes “mice”*
URAQT t1_jcj0vtn wrote
Looks down at John Steinbeck’s lesser known trade paperback sequel “Of mice, not Menin”.
MrmmphMrmmph t1_jcjs6tn wrote
Old Spice, by Menin
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austinrunaway t1_jcjdaf7 wrote
Hahhahahahha
DarkTreader t1_jcmmw7b wrote
Why not both?
ralpher1 t1_jcj3mqs wrote
What we need to do is feed it to dogs and cats because they deserve longer lives.
HeavensCriedBlood t1_jcizib2 wrote
Raw? Blend it and I'm down.
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Brokenspokes68 t1_jci4vw8 wrote
This smells of a wildly optimistic supplement claim one would hear on AM radio.
TheBeardofGilgamesh t1_jcim4ro wrote
Alpha brain
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shindleria t1_jcjxw80 wrote
With the host in studio and the “doctor” on the line using what sounds like an old truck stop pay phone.
borntoflail t1_jcjh5tk wrote
On the bright side a casual google seems to show that menin supplements aren’t a thing… yet…
MTI35 t1_jcxxyc6 wrote
If something can reduce aging and it's unavailable how is that to a good thing?
borntoflail t1_jcz8o9d wrote
Within context of the exchange it would imply that the article was attempting to boost sales of supplements and ultimately wasn’t containing very solid research.
If the supplements don’t exist, then one can infer that the research might be done without ulterior greedy motives.
Any-Assumption-7785 t1_jd2x4e9 wrote
Big Nut is after your moneyz.
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gwendolynrutherford t1_jd6suf1 wrote
It's D-serine that drives menin production, and you can find it in amino acid supplements.
source: I read the article!
borntoflail t1_jd6u84u wrote
We don’t do that here.
gwendolynrutherford t1_jd808jy wrote
A tip o the hat and tender nod of understanding my comrade
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Next-Mobile-9632 t1_jchev9n wrote
Internet says of the nuts containing the amino acid D-Sirine, peanuts are the highest, so I assume peanut butter would be included--Soybeans are found in a lot of veggie burgers--eggs and shellfish
AtuinTurtle t1_jciptcp wrote
Brought to you by the National Peanut Butter Council.
louiegumba t1_jcj9a6s wrote
Mr peanut is a classy MF I would listen to
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Xerenopd t1_jcicjet wrote
Is aging a disease that everyone has?
tkuiper t1_jciz0di wrote
Personally that seems a better scientific viewpoint. I feel like there's far too much mysticism surrounding death by aging.
Its a hard and complex problem, but so is cancer and spaceships. It seems strange to fight issues like cancer and Alziehmers, but avoid addressing the mechanism that underscores a majority of diseases: age.
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Man0fGreenGables t1_jcio73l wrote
Yes. It’s a terminal illness.
austinrunaway t1_jcjde9j wrote
Its more like falling apart. Yes we all fall apart because time progresses.
chance_waters t1_jcjf6go wrote
So long as there is energy to inject into a system falling apart is not mandatory, age related death is 100% a curable disease
SerialStateLineXer t1_jcjnfj7 wrote
To be clear, you can't reverse aging just by heating up or overfeeding an old person. The point is that aging and death on human time scales are not an inevitable consequence of the laws of thermodynamics. Entropic changes can be reversed using an external source of energy (e.g. you can use energy to set up bowling pins after knocking them down). With the right technology, it is absolutely possible to repair aging-associated damage and restore an old person to a youthful state. It's a very difficult engineering problem, but there's no theoretical reason it can't be done.
Nastypilot t1_jcktg72 wrote
In fact, we're pretty close to achieving it.
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Georgie___Best t1_jcjy9qd wrote
The human body, surprisingly, is more complex than the entropy of a simple system.
LordGarryBettman t1_jcwx7le wrote
You mean, not surprisingly.
Georgie___Best t1_jcxaf5b wrote
I was going for sarcasm, but yes.
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ZmeiOtPirin t1_jcjrdex wrote
On a very long term timescale, death actually isn't curable. That's because for our genes that are running the show, death is a feature not a bug. It's crucial for evolution and even if it's possible to have a species that evolves without its individuals dying, if that slows down evolution then they would be outcompeted by faster evolving death-based species.
So in order to stop death you would need to devise an entirely different form of life where death doesn't accelerrate evolution AND have it outcompete the previous life.
That seems an incredibly hard task so death may not be curable after all. If the problem is smart living beings don't want to die and are actively fighting it, then nature would simply evolve beings that like dying.
Georgie___Best t1_jcjyhdr wrote
No.
We evolved in a way in which we die.
That doesn't mean it's impossible to overcome the design flaws of evolution.
We are a very long way away from this btw. We have barely scratched the surface of the underlying biology.
ZmeiOtPirin t1_jckinr1 wrote
Like I said, that's not a flaw, it's a feature.
Georgie___Best t1_jckp1yf wrote
"Flaws" and "features" are arbitrary words that we assign to things as humans. I think you'll find most people, if given the choice, would choose not to die. So in that sense it's a "flaw" for us, isn't it?
Evolution on the other hand isn't an entity with foresight and planning. In that sense nothing is a flaw or feature. It's literally just survival of the fittest.
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ZmeiOtPirin t1_jcmxtmz wrote
>Evolution on the other hand isn't an entity with foresight and planning.
A true statement so often absent-mindedly repeated, it actually interferes with some people's understanding of evolution. The metaphor reflects reality better than the nihilistic assertion that nothing matters in evolution.
> In that sense nothing is a flaw or feature. It's literally just survival of the fittest.
Yeah and what I've been telling you is that the fittest species are those that utillise death rather than some immortals. Being immortal is actually pretty bad in terms of the long term fitness of a species.
Georgie___Best t1_jcttxk0 wrote
>The metaphor reflects reality better than the nihilistic assertion that nothing matters in evolution.
No one made any assertion that nothing matters in evolution. Somewhat ironically, given you are talking about absent-minded misunderstanding, you apparently need to refresh yourself on what nihilism is.
>Yeah and what I've been telling you is that the fittest species are those that utillise death rather than some immortals. Being immortal is actually pretty bad in terms of the long term fitness of a species.
So you're under the impression that mankind is still under the same selection pressures as we were 100,000 years ago? Or is it that that we shouldn't bother with medical interventions, because we are lowering the fitness of the population by allowing people to live/reproduce when they otherwise wouldn't?
It's genuinely amazing how people with the least understanding are always the ones who speak with the most authority. The evolutionary benefit of death is something I would expect a high school student to understand. The fact that we are able to escape the consequences of evolution in the modern world is something I would expect a kid to know.
ZmeiOtPirin t1_jcuahjd wrote
>It's genuinely amazing how people with the least understanding are always the ones who speak with the most authority.
>The fact that we are able to escape the consequences of evolution in the modern world is something I would expect a kid to know.
Imagine writing these two statements together.
I'd respond to the rest of your comment but I doubt you'll take anything I say seriously. Just FYI though, humanity isn't currently escaping evolution by even the barest stretch of the imagination.
Georgie___Best t1_jcve68m wrote
You deny that we are able to overcome any of the restrictions evolution has imposed on us? So any time a child is born premature and survives due to modern medicine, when they would have died otherwise, that is what exactly? Any time someone with a genetic predisposition to cardiovascular disease is saved with at coronary artery bypass, what are we doing if we are not preventing a consequence of evolution?
Maybe try having a few days think before replying this time.
ZmeiOtPirin t1_jcvkln7 wrote
Dude your comment is so utterly ignorant, you should maybe have a few days to read about what evolution is before writing.
Evolution isn't merely about dying. Yes it's a big part of it, and I did call it "crucial" too, but there's so much more to the process, it isn't even the biggest part. Number one, it's about spreading genes. Procreation is even more important than survival and leads to evolution on its own. Stopping death doesn't stop evolution by any means...
Secondly none of the cases you listed are examples of beating or preventing evolution or anything. They are just examples of a species dealing with problems in its own way.
You don't think beavers building dams or termites building a mound to avoid dying from floods is them cheating evolution, do you? Just because you make things to avoid dying doesn't mean you're avoiding evolution. Quite the contrary, you're fulfilling it. Your beneficial traits allowed you to survive where you otherwise wouldn't have and henceforth the living world will be more filled with the genes providing these beneficial traits. Smartness, culture and transfer of knowledge, as exemplified by humans, are clearly successful traits and they have lead to us becoming the most dominant mammal on Earth. To the point that humans and the species we use for food make up the weight of 90% of all mammal biomass... That's evolution in action.
And when some unfortunate person in Brazil or India or the US can't be saved by a coronary artery bypass because it isn't free and they were born too dumb to have a nice job and afford it, or too sickly to keep up with all their disases or too asocial to have a nice support network; then that would be evolution too. But the far more common type of evolution in the 21st century would be when some human beings are having more kids raised to adulthood than others. Evolution is here, alive and well.
Georgie___Best t1_jcvl2vb wrote
>Evolution isn't merely about dying.
Please highlight where I said this.
>Evolution is here, alive and well.
Or where I claimed evolution is something that isn't happening.
Like I said, you should have spent more time reading/thinking before replying.
ZmeiOtPirin t1_jcvlrgk wrote
There's not a single interpretation of "preventing a consequence of evolution" that is factually correct. You do seem to believe and imply that avoiding death prevents evolution. I'm not really sure what you think "consequences of evolution" are, but death is no more a consequence than living, breeding or having a drink by the beach are evolutionary consequences.
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Georgie___Best t1_jdzpgwd wrote
ZmeiOtPirin t1_jdzrxgr wrote
Hm? I see a removed comment above yours if that's what you're referring to.
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austinrunaway t1_jcjfxvp wrote
How do you isolate energy. Thats very vague....the variables are endless. No ones, except identical twins, genetic is the same. What's the energy made of?
chance_waters t1_jcjhph8 wrote
It's just how systems work in a general sense, energy counters entropy, if you can put new energy into a system you can maintain order. Fundamentally bodies don't need to break down as there's nothing theoretically irreplaceable or irreversible, so long as there is still energy available to inject into the system.
We are biological machines that evolved to reproduce and pass on genes, and the genes that consistently resulted in survival with successful reproduction formed a machine with a lifespan as long as ours. Many other creatures live far longer or far shorter lives.
Thx4Coming2MyTedTalk t1_jcjtam2 wrote
That’s a very simplistic view of a system that can take in outside energy and is designed to repair itself.
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Dempsey64 t1_jcwaot9 wrote
Unless you die young
The_Humble_Frank t1_jclcgmf wrote
its the natural wear down of any operational machine. you can't run a machine without creating wear.
Unlike strictly mechanical machines that are repaired and maintained by an independent operator, electrochemical-mechanical (aka Biological) machines, continuously gradually repair themselves with micro-patchwork fixes instead of whole component changes (though to a limited extent that is possible now with the aid of independent operators, called surgeons and medical teams), and the rate at which those fixes occur happens varies on the available resources, how easily those resource can reach the area (good luck on joint repair), what else in the total system needs repair, and how good the total system is overall operating.
But the repair systems themselves also incur damage, and poor patchwork makes future repairs more difficult. the ability to process materials lessens, the marrow creating the biochemical slurry that transfers resources throughout the system lessens in quality as damage builds up. Harder to repair systems get filled with quick filler scar tissue that doesn't properly mimic the function of the damaged tissue, and eventually one or more of dozens of critical systems can no longer maintain to operations at a minimum necessary levels of function, creating cascading terminal stresses on the remaining functioning systems.
Embarrassed-Coast216 t1_jcjxtv8 wrote
Seems like menin is a relatively newly discovered protein which can suppress tumors.
Here’s a link that goes into its functionality a bit more.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3741089/
Sounds like promising research.
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keziahw t1_jcingzx wrote
You know it always makes up the citations, right?
reddititty69 t1_jcinrxr wrote
That first one is sus; just based on the title.
SerialStateLineXer t1_jcjnke9 wrote
I asked Chat GPT about a seminal paper in a niche area (rare genetic disease), and it got the citation right. I think the key is that it has to be a paper that's discussed in the training data.
whatabouteee t1_jcio1pi wrote
FYI, chat gpt doesn’t actually work like you think it does. It will write something that looks right, but it just makes it up. Look at the references it is citing for the statements and you will see that it is really hit or miss in terms of facts
matt2001 t1_jciot4r wrote
Good catch. Ref 1 is acne... I don't have the chat4, but I've seen YT's that say it is much better. I deleted the comment.
Heroine4Life t1_jcipnbt wrote
I replied to your comment before you deleted (on my side). All 3 references were garbage (1 was incorrect and irrelevant, 2 were fake), and most of the statements it made were unsupported.
matt2001 t1_jcitw59 wrote
Thanks for the feedback. I hope the next version is accurate, as I do like the format. I have been using it to write code in R, and it has been doing really well. So, this is an eye-opener.
TirayShell t1_jci15m6 wrote
Then all we have to do is eat the mice.