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Why isn't this legal yet anywhere globally?

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Oral cannabis products, opposed to all those other methods

If you read the article you would know that it was published in PLOS ONE, an open-access, peer reviewed journal. Norml merely reported a summary.

So post that. Primary sources are always more credible.

It's fully legal in over 2/3rds of North America. Several other countries, and many localities have either legalized or decriminalized it.

PLOS ONE is

I've been taking mine as a suppository. Just shove some trees in my keister. Am I doing it wrong?

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No reason to legislate against it then right?

Sounds like it’s less damaging than alcohol.

Idk but I might need to try

Google it yourself?

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Because some fat cracker jack with stakes in the nylon industry existed almost 100 years ago

It's not enough.

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You joke but the dispensary has this option.

The ole, 'I've got a chance to call someone out for a bad title but then it backfired!' routine.

Better start locking up all the weed smoking degenerates. All the people who inject weeds too

Imagine injecting thc when you’ve really got that full addiction going

The rules state that a media summary of a peer reviewed article is acceptable. If the submitted article doesn't link the peer-reviewed article directly (this article does) then you're supposed to leave a comment to the peer-reviewed source.

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Or read the article before you review it ?

So is reading the article before posting

rectal valium exists because the walls of your rectum are really good at absorbing the valium into the blood stream (diastat- rectal valium for use when your having a siezure and need it to stop pronto).i would thing an rectum cannabis would be just as fast acting so there's merit to a suppository dosage form.

Mods, please ignore my report. On my first read, I missed the quote from the researchers about safety. Given the source, I was (perhaps understandably) suspicious of the enthusiasm.

Oral as opposed to inhalation. Australia has A Thing about inhalation drugs. Cigarettes are so heavily taxed that a pack of 25 costs around $50. A pack a day smoker would spend more than $12k per year in Australia.

There has been a lot of resistance to the idea of just replacing tobacco with weed in case it sends lung conditions back to number 1 place on our death list. Studies about other methods of delivering cannabis to your body are really useful to dispel some of the doubt.

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I’ve seen delta 8 lube in a smoke shop, so I am not surprised.

Tried this method with coke once after not being able to get any more up my nose. The pain was immense.

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It is for sure in much of the US pacific northwest. Just go into any dispensary and ask to see the tinctures.

The Innuendo, or Italian Suppository.

Wh.....what

Easy solution. Just use a vaporizer for weed.

Tingles the gonads. Opens up previously unexplored dimensions of tactile pleasure. Or so I’ve been led to believe. Never used it myself.

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That’s still an inhalation method. Anything other than air - whether it’s water vapour or wood smoke or literally any other kind of air pollutant - inhaled into the lungs increases the incidence of lung disease. Australia has A Thing about inhalants.

Seems to me you'd get high faster with a vaporizer. All that time unpacking, getting your pants down, getting it in, getting pants back on.

Nah, I'll vape.

Good god I could only imagine.

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Barring “hurr durr Big Beer lobby” and “weed banned cuz racism in 60s”, it’s not studied thoroughly yet. For now we know that smoking weed before an individual turns 25 hurts brain development with repercussions still unknown. And I guarantee you kids will be smoking joints since school. Alcohol, due to its effect and withdrawal effects, is too strong of a drug to be used as regularly by a random individual comparing to weed, so please don’t bring it to discussion.

Edit: Oh no, I hurt the Big Weed feelings.

Any trial with weed just has a bunch of happy people sitting around eating all the snacks too damn high to notice any negative side effects. Stop harassing my buzz bro!

Lord I just remembered there is such a thing as butt chugging! Welp that ruined my mind again.

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I'm guessing the pain was gone in a few seconds.

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FAR LESS, why do you think they have been trying to destroy it for years?

It's one of the few medications that doesn't come with a huge list of detrimental side effects.

Truly God's gift to mankind but many are too greedy to see it.

No one would smoke 25 joints per day to replace a tobacco habit. That’s bonkers.

Anyway. Boof it.

I’m headed there today to get the vaginal suppositories. Got me some serious cramps.

Gives your nether regions the hunger.

—ButtMunch

If anyone wants a little more info: https://pressroom.cancer.org/SmokingAndCancer#:~:text=The%20findings%20reinforce%20the%20message,if%20they%20continued%20to%20smoke.%E2%80%9D

A comparator group would have done this study wonders.

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I don’t have a uterus or vagina but I do think that’s the purpose.

Yeppers! That why the pharmacist recommended them. Also, they zoot you to Jupiter if you put them in your butt. :)

> Boof it.

Is that you Supreme Court Justice Brett Kavanaugh?

Hunting for your next Devil’s Triangle I see…

Oh no. Boof = butt. I’m old school, unlike that fellow and his chums who’ve all got oral fixations and have filled their calendar with events in which they funnel booze into their gullets and scar young women for life.

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I'd be more worried it would affect obesity more.

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I don’t think “they” want us dependent on alcohol. I do think there are huge alcohol lobbyist that conspire to keep marijuana illegal in a lot of states.

I do think there are still stigmas held against marijuana especially by the older generation.

next you'll tell me they want to make my whole life a rental/subscription model

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It’s not a malicious conspiracy, it’s purely about money. If it was more profitable to keep people happy and healthy, they would.

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Isn't it funny how things that have serious withdrawals are legal? Not just alcohol either, look at many prescriptions. "they" are predators, they get people addicted and reap the profits. Think this "fentanyl" is just a coincidence? Just happens its right after they get caught massively over-prescribing opioids?

Oh boy… I wish I could tell everyone about my experience growing up in small Christian-wannabe town turned “ghetto” (I hope you know what I mean) and also going to a private Christian school by a HUUUUGE military base. The evangelicals are INSANE and there are a LOT. Nervous and anxious to their core, never leaving their bubble.

This is what weed being illegal and alcohol being legal represent to me. The patterns are too common and precise to be a coincidence. It’s narcissistic to the core.

These private Christian schools are basically trying to raise mini-ceos. These are frat boys. These are politicians. They’re becoming doctors. This is white nationalism. This is what’s keeping weed illegal. I want to be wrong. “town hall syndrome” is what me and my buddies that have come to the realization call it

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Mine have made a world of difference for my health.

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Idk the longer we live the more we will spend. I don’t think it’s a conspiracy, I just think it’s a byproduct of capitalism/greed. I’ve never had a doctor urge me to stay on a medication beyond it’s necessary treatment, and I have some significant medical issues. My doctors suggest things like acupuncture, physical therapy, meditation and mindfulness practices, and are hesitant to prescribe meds.

Yeah there is no grand conspiracy. Just normal greed

It’s… Reefer Madness!

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Boofing may actually make it less effective.

Sure, more thc enters your bloodstream, but an important thing for oral cannabis is the first pass metabolism where thc is converted to 11-OH-THC, which is just as, if not even more psychoactive than thc.

Boofing may be as short lived as inhalation, while oral consumption works for hours on end.

Citation 31 from the PLOS study:

>Regular recreational users according to the Australian National Alcohol and Drug Knowledgebase (NADK) [31] use 150-250mg THC per day with unknown concentrations and doses of the hundreds of other cannabinoids, including CBD.

This seems quite extreme with the citation linked stating that 76% report < 5 "cones/joints/bongs used per occasion" and only 14% report usage of "every day". This citation isn't particularly relevant to the study other than to compare the dosage prescribed vs. 'average', but data point seems off nonetheless.

NADK

The older generation now being boomers, almost all of whom have smoked pot.

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it's almost like they keep it illegal at a federal level to generate ad rev from clickbait. they've studied it for 100yrs now it's an effective medicine.

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I've put MDMA up my butt but weed in the vajay? That's just cray (z)

It’s Occam’s razor. Social conservatives are scared of drugs and there’s lots of money to be made in keeping drugs illegal. The general principle is don’t waste time on conspiracies when simple linear answers exist.

I actually don’t have enough of that enzyme that does the conversion so it takes about 4 hours for me to feel any effect and then I am extremely high for about 3 days. My first experience with oral administration was an absolute living nightmare where I was unable to leave what I thought was a sofa for days. Turns out it was an unassembled ikea futon, essentially a pile of boards that I laid on for 72 hours as people came and went all around me.

Hell yeah! Down with alcohol, it's truly a poison.

I saw an article recently saying that cannabis does not have any pain relieving effects other than people's perception https://www.cnn.com/2022/12/02/health/marijuana-pain-control-wellness/index.html

I happen to live on a border town in Wisconsin and our local smoke shop carries D9 edibles. We even had a stall during our town summer festival selling them as well as smokables in the middle of it all. I never thought I'd live to see the day. First time I even heard of legally purchasable THC products in WI was while vacationing in the Dells and saw an ad for a shop next to the jerky place in the middle of the main tourist center. Now I know what that first guy to buy grass from Colorado felt like. Pretty sure I had the same expression on my face as he had in the photo.

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Yeah that sounds horrible.

Considering my body has some weird kinks with methylation and breakdown of estrogen metabolites.... Maybe I should do an ultra low dose the first time I try edibles x) do NOT want to experience a 3 day trip.

So just a regular conspiracy then

Like the cookies I bake at home.

How do they feel about inhaled medicines like albuterol? Or inhaled corticosteroids? My sister lives in Brisbane and just had a severe asthma episode. Does the inhaled drug stigma extend to those drugs?

I used to smoke 25 cigarettes per day. I did quit 15 years ago. And granted, I didn’t replace it with anything at the time, I couldn’t fathom attempting a 1:1 replacement with joints. I didn’t try marijuana until my 40s in order to address medical issues. People with epilepsy and cancer who need round the clock relief usually don’t rely on inhaled THC anyhow because it’s short acting.

It’s Cytochrome P450, a liver enzyme. So you may be completely fine.

Yeah 150-250mg seems a little crazy for regular recreational use. When I used to use edibles a single 15mg definutely did the trick for me. Maybe I'm a lightweight but I can't even fathom what 10, let alone 16 of those would do to me holy fookin shite

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How is Delta 9 anyhow? I'm not too experienced with weed, so I don't know how it differs.

Seriously, those numbers are so messed up. I ingest fairly often, not every single day, and 10mg is a nice high. If I was taking 150-250mg a day I would be convinced life isn't real.

I can't even imagine what that much would do. I usually take like 15mg at night and it does the trick. One time I took 20-25mg and I could barely walk straight.

Your perception is all that matters, though. Perception of pain is perception of pain? How much pain do you perceive while high? Less. Perception.

But pain itself is a perception...

Altering that perception is the important part of treating pain. Blocking pain receptors is irrelevant in comparison.

Erm..... Yes, the enzyme to metabolize estrogen in the liver is also of the cyp 450 family.

Cyp (450) 3a4.

Cyp3a4 as well as cyp2c9 are the ones responsible for thc metabolism.

Both of the cytochrome 450 family.

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Did you learn this through genetic testing?

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Granted I have very little experience with old fashioned cannabis derived THC, but Hemp derived D9 does the job well. An effective dose for me is about 20mg at 260lbs especially if I take it before a meal (as opposed to after).

I actually prefer D8 personally with an effective dose of 40mg. Feels much less fuzzy which allows me focus and enjoy movies or games like they're brand new even if I've seen them 100 times.

Unfortunately my local smoke shop is choosing to only stock D9 because it's "real" so my dwindling supply gets much less attention than I'd like.

I have known plenty of people who smoke 25+ cigarettes per day. When I was a smoker I thought I was atypical because I’d smoke about 1/2 of a 20 pack each day. I know several 2 packs a day smokers.

This is far from true. The hippies were a tiny tiny section of people in the 60s/70s. The vast majority didn't smoke pot when younger. This pew research shows just 4% had smoked pot in the year 1969.

https://news.gallup.com/poll/6331/decades-drug-use-data-from-60s-70s.aspx

Boomers are the biggest new consumers of cannabis but they doesn't mean they used in the 60s. Pop culture just makes you think they did because the hippies were the loudest group and most written about group of that time. Plus, they are idolized because of their anti-establishment ideas

Not true, as we get to senior status, the government and businesses start having to pay for us to live. Not to mention we end up not being in shape to work and retire so theres really no use for people in a business sense once you hit retirement age, cant even have kids in most cases and the risk for mental diseases/illness drastically go up the older you get so that alone creates even more problems for bigwigs to have to pay more for assisted living

I used to smoke 1g/day. Assume its 10% THC, thats 100mg easily.

While I agree with your point that the government just wanted all forms of marijuana in general to be outlawed, if you think Reefer Madness wasnt a conspiracy against weed, then you need to actually look at what was contained in that footage. I mean for fucks sake the poster even shows people smoking pot with weird anti-weed slogans

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Orders of magnitude less. You couldn't survive taking 50x the typical dosage if it wasn't the case. Active:lethal dose ratio is very often a direct predictor of the damage the drug is doing. That, how dissimilar it is to endogenous neurotransmitters, and how much the systems the interact with interfere with physiology. 4-ho-dmt aka psilocin, the metabolized version of psilocybin in mushrooms, is a structural cousin of tryptophan, is a selective agonist to a subtype of serotonin receptors associated primarily with non physiological functions like mood, perception, cognition, sense of self, and has a LD50 on the order of dried pounds.

Literally in rats about 3g mushrooms per kg of rat for LD50. That's basically going to be more plant material than you could even bring yourself to swallow before puking. Still risky in other ways, especially without a sitter, or inexperienced taking too much, but outcomes tend to be net positive or neutral when taken with care. Sometimes even people who take way too much with no experience make it through with borderline miraculous experiences like Paul Stamets stutter cessation and some cases of nerve growth repair. And certainly at least temporary remission of depression, anxiety, pain disorders, and other semi-common mental illnesses. Can't say the same for alcohol, or any other significant drug sans cannabis.

More dangerous substances tend to interact with the broad spectrum of a neurotransmitter, or multiple, usually with dopamine, GABA, norepinephrine, or opioid, some adrenaline ones. Or in the case of alcohol, GABA + NMDA iirc. And anyone who knows drugs knows that combining those two classes together is extremely risky, but that's just what alcohol is naturally.

NMDA (antagonists) in isolation are also interesting because it basically just affects south of the head nerve function. Hence, anesthesia and dissociative anesthetic experiences that are powerful but still have a pretty wide range of potential survivable dose compared to alcohol, although less than HT-2A-based stuff and cannabis. Often dangerous things are reputable inhibitors which just trick existing signals to stay rather than introducing cousins of what's already there that fits the same key hole. And when receptors and endogenous agonists downregulate to try to bring you back to hemeostasis, after which the false "on" switch is removed, your physiological systems start to have issues because of not enough signaling. By contrast, HT-2A agonists like psilocybin have even been shown to stimulate nerve and neuron growth through a similar pathway that light cardio does.

But anyway, I'm no neuroscientist and this stuff gets confusing very quickly. But to reduce it, alcohol is basically one of the most dangerous drugs there is, especially because it's culturally sanctioned, easily available, and liquid at room temp, therefore comes across as less harmful. The preparations for other drugs are just much more unique by comparison to alcohol being little different than pouring a ginger ale

You haven't met my roommates, then.

(It's not replacing a tobacco habit, to be fair)

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I go through a tincture of ~1000mg of d8 THC in ~3 days.

This I learned by googling.

My issues with methylation I noticed when I took methylsulfonymethan for skin and nail benefits and it really messed me up x)

As for my issues with estrogen..... I have to take endogenous estrogen, and despite very low doses, my blood levels were sky high, way higher than they should be.

Correct. In Wi the Tavern League is a huge lobby and absolutely opposed to legalization.

And you're a functioning adult?! Like a job and pay bills with real sponsabilities?

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Their Reddit name is Wittis but their human name is Shaggy and they have a pet dawg named Scooby and their functioning adult lives are hunting criminals

The source is in the article

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Are you perceiving pain? Smoke this, now are you perceiving less pain?

Seems like it’s working to manage pain then

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Oh that’s interesting.

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Check r/delta8 for recs on good brands you can order online. Personally I like Delta Farms, 3Chi, and Nature’s Purpose.

I think “they” do want us dependent and addicted to substances and hobbies that keep people living paycheck to paycheck.

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I have high estrogen and low progesterone so I take progesterone for two weeks of the month.

I’ve heard of genetic testing for the MTHER gene, so I was wondering if the Cyp450 was a similar test.

This. Older folk like to take claim Rock n Roll, Woodstock, psychedelic art, and literature as part of their contributions to culture, but hippies were widely scorned and demonized at the time and the war of drugs was meant to criminalize their behavior.

Weed is still illegal for one reason

"You just expect me to admit that I've been wrong the past 50 years and ruined people's lives and should probably face repercussions for hiding the truth to cover my misdeads?"

No smoking. Eat your greens.

By the mid 1970's this percentage was much higher.

Higher tolerance is a thing. His body is used to it at this point

We never inhale just air, there is always dirt and dust. As long as they are not toxic our lungs can handle that.

Too bad the federal government is 50 years behind the times

I've been making cannabis tinctures for almost 10 years now.

It is wonderful to have a selection and I can set the dose. Need to workout, well six drops of this one. Want to murder a range rover driver, I need 12 drops of this one to chill. Want to extra enjoy a movie well it's time for 18 drops of this one...

If your $200 pill doesn't come with side effects how else can they sell you the $300 pill?!

I meant spend in terms of pharmaceuticals, I failed to clarify.

You think the guy who didn’t read the article read the rules?

Oral is one of my favorite als

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Quantities matter.

Work somewhere that dust is visible and don’t wear a dust mask and tell me how well your body handles it.

Vape is VISIBLE particulate, if you think it isn’t gumming up peoples lungs while still being “non toxic” you are kidding yourself.

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Anyone know the best oral products? I've been smoking daily for a few years now and have tried edibles but they've never worked, so I'm curious if anyone has had the same experience/found a healthier alternative

Life is real ??

I really want to know about my method, the dry herb vaporizer. I know it's not healthy, but I really want to see it versus smoking.

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